Virology 101

A new class is starting at virology blog: Virology 101.

I began this blog in 2004, to give back what I’ve learned from studying viruses for 30+ years. I’ve written many posts on basic virology, but they tend to disappear with time. To remedy this problem, I’ve collected all these posts with links back to the original article, arranged by topic. They are typically short and easy to read; if you start from the top, soon you will have a good basic understanding of virology.

I’ve also included relevant episodes of the podcast TWiV, where we discuss basic virology about once a month.

For the more adventurous, I list video podcasts from my new Columbia University virology course, W3310; and my lectures to medical and undergraduate students. I am replacing the previously posted lectures from my graduate virology course, G6021, with newer lectures from the 2010 spring semester as they become available.

If you are specifically interested in influenza virus, there is always Influenza 101.

The most recent additions are shown by *.

Class will always be in session: there is much more to come.

With this virology course you also get access to a virology professor. If you have any questions, send them to vincent@virology.ws.

Basic Background Information

What is a virus? (W3301)

Introduction to virology I and II (Medical school lecture)

What is a virus?

Are viruses living?

Discovery of viruses

What color is a virus?

How viruses are classified

Virus classification (TWiV 43)

Simplifying virus classification: The Baltimore system

Viral genomes (TWiV 49)

Genomes and genetics (W3310)

The infectious cycle lecture (W3310)

Measurement

Detecting viruses: The plaque assay

How many viruses are needed to form a plaque?

Measurement of viruses by end-point dilution assay

Virus Structure

Virus structure (TWiV 39)

Virus structure (W3310)

Attachment and Entry into Cells

Virus entry into cells (TWiV 46)

Attachment and entry (W3310)

Nucleic Acid Synthesis

RNA synthesis (W3310)

Making viral RNA (TWiV 60)

Reverse transcription (W3310)

Reverse transcription (TWiV 66)

Genome replication of DNA viruses (W3310)

Transcription and RNA processing (W3310)

Protein synthesis

Translation (W3310)

Virion Assembly

Assembly (W3310)

Pathogenesis and Immunity

Infection Basics (W3310)

Host Defense (W3310)

Virus-Host Interactions (W3310)

Viral Pathogenesis (Medical school lecture)

Acute Infections (W3310)

Antigenic variation explains recurring acute infections

HIV Pathogenesis (W3310)

Innate responses lecture (G6021)

Transformation and Oncogenesis (W3310)

Innate sensors of DNA

Immunopathology: Too much of a good thing

Innate immune defenses

The inflammatory response

Adaptive immune defenses

Adaptive immune defenses: Antibodies

Virus neutralization by antibodies

The complement system

C1q and the collectins

Natural antibody protects against viral infection

Prevention and Control

Vaccines (W3310)

Antiviral Drugs (W3310)

Tamiflu-resistant pandemic influenza H1N1 virus selected by prophylaxis

Vaccines lecture (Immunology course, different from W3310 version)

Discussion of new HCV antiviral on Futures in Biotech 60
(download the HCV part of the discussion here)

Evolution and Emergence

*Viral Evolution (W3310)

*Emerging Viruses (W3310)

Viruses and the tree of life

The abundant and diverse viruses of the seas

Chikungunya: An exotic virus on the move

Lujo virus, a new hemorrhagic fever virus from Southern Africa

The error-prone ways of RNA synthesis

The quasispecies concept

Viral quasispecies and bottlenecks

The number of possible viral variants

Pushing viruses over the error threshold

Increased fidelity reduces viral fitness

Why don’t DNA based organisms discard error repair?

The trajectory of evolution

Virulence: A positive or negative trait for evolution?

Topics that don’t fit anywhere else

*Unusual Infectious Agents (W3310)

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  • Kurniawan_oki1
    I really interest with your subject Mr. Vincent
  • duncan
    In an interview for the AIDS-documentary "House of Numbers", Dr. Luc Montagnier – Recipient of the 2008 Nobel Prize in Medicine for the discovery of the Human Immunodeficiency Virus (HIV) – spoke out for nutrition and micronutrients in the fight against HIV/AIDS:

    In the interview (see video below), Dr. Montagnier stated that:

    http://www.youtube.com/watch?v=WQoNW7lOnT4

    There are many ways to decrease the transmission of HIV just by utilising simple measures such as nutrition, giving antioxidants, hygiene measures and fighting the other infections that are present in patients.
    If you have a good immune system your body can get rid of HIV naturally.
    We should push for combinations of measures, such as antioxidants; nutrition advice; nutrition; fighting the other infections that are present in patients ­ such as malaria, tuberculosis, parasitosis and worms; education and promoting genital hygiene.
    People always think of drugs and vaccines because there is no profit in nutrition.
    If you take a poor African patient who has been infected with HIV and you build up their immune system it should also be possible for them to get rid of HIV naturally.
    All of the above constitutes important knowledge which has been completely neglected.
  • SDS
    It is true that good hygiene and diet are very important for controlling the secondary, and eventually fatal, infections that are the result of HIV infection. With good habits and anti-retroviral drugs, an HIV+ individual may be able to live a long, relatively normal life. However, I can not see how clean habits alone can "get rid of HIV naturally." The virus effectively evades and diminishes cell-mediated immunity.
  • DaJuan
    Awesome, in the way you have set up this forum to inform, teach, and breakdown virology in a way that is digestible, for lack of a better word, thanks I will continue to tune in.
  • Re: H1N1 Letter Addressed to Health Care Professionals

    http://video.google.com/videoplay?docid=-8674401787208020885#
  • p mckenzie
    Thankyou for taking time to create these online classes for the masses.
    I share them with my family and staff at the hool where I teach.

    We are all nervous about H1N1 after our experience wit SARS.

    regards. PM.
  • jaleeskhan
    good attempt
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