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Virology Course 2014


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Virology – Biology W3310/4310

Spring 2014

viral video

This Columbia University virology course is offered each year in the spring semester.

Lecture Schedule, Spring 2014

Date Topic Reading Slides Videocast
1/22 Lecture 1: What is a virus? Flint Vol I Chp 1
•The virus and the virion
•Cell size and scale
•Pandoravirus
pdf YouTube
1/27 Lecture 2: The infectious cycle Flint Vol I Chp 2
•Influenza virus growth in eggs
•Influenza hemagglutination inhibition assay
•The amazing cells of Henrietta Lacks
•The Wall of Polio
•Small fragments of viral nucleic acid
pdf YouTube
1/29 Lecture 3: Genomes and genetics Flint Vol I Chp 3
•The Baltimore scheme
pdf YouTube
2/3 Lecture 4: Structure Flint Vol I Chp 4
•Structure of influenza virus
•Virus images at ViperDB
pdf YouTube
2/5 Lecture 5: Attachment and entry Flint Vol I Chp 5
•Influenza virus attachment to cells
•Influenza virus attachment to cells: Role of different sialic acids
•A single amino acid change switches avian influenza H5n1 and H7N9 viruses to human receptors
pdf YouTube
2/10 Lecture 6: RNA directed RNA synthesis Flint Vol I Chp 6
•Influenza viral RNA synthesis
•The error prone ways of RNA synthesis
pdf YouTube
2/12 Lecture 7: Viral DNA replication Flint Vol I Chp 9 pdf YouTube
2/17 Exam I
2/19 Lecture 8: Transcription and RNA processing Flint Vol I Chp 8 and 10 pdf YouTube
2/24 Lecture 9: Reverse transcription and integration Flint Vol I Chp 7
•Museum pelts help date the Koala retrovirus
•Unexpected endogenous retroviruses
pdf YouTube
2/26 Lecture 10: Translation Flint Vol I Chp 11 pdf YouTube
3/3 Lecture 11: Assembly Flint Vol I Chapters 12 and 13
•Packaging of the segmented influenza virus genome
pdf YouTube
3/5 Lecture 12: Infection basics Flint Vol II Chapters 1 and 2
•Transmission of influenza
•
Slow motion sneezing
•
Chikungunya an exotic virus on the move
•
Do the tropics have a flu season?
pdf YouTube
3/10 Lecture 13: Intrinsic and innate defenses Flint Vol II Chapters 3 and 4
•The inflammatory response
•
Natural antibody protects against viral infection
pdf YouTube
3/12 Lecture 14: Adaptive immunity Flint Vol II Chapter 4 pdf YouTube
3/17 Spring Recess
3/19 Spring Recess
3/24 Lecture 15: Viral virulence Flint Vol II Chapter 2
•Antimicrobial peptides induced by herpesvirus enhance HIV-1 infection
•
HIV gets the zinc finger
pdf YouTube
3/26 Lecture 16: Acute infections Flint Vol II Chapter 5
•Acute viral infections
•
Chronology of an acute infection
pdf YouTube
3/31 Lecture 17: Persistent infections Flint Vol II Chapter 5 pdf YouTube
4/2 Exam II
4/7 Lecture 18: Transformation and oncogenesis Flint Vol II Chapter 7 pdf YouTube
4/9 Lecture 19: Vaccines Flint Vol II Chapter 8
•Influenza virus-like particle vaccine
•
Poliovirus vaccine safety
pdf YouTube
4/14 Lecture 20: Antivirals Flint Vol II Chapter 9
•Treating hepatitis C by blocking a cellular microRNA
•
TWiV 270: Homeland virology (developing a smallpox antiviral)
pdf YouTube
4/16 Lecture 21: Evolution Flint Vol II Chapter 10 pp 311-333
•Virulence – a positive or negative trait for evolution?
•
Increased fidelity reduces viral fitness
•Why do viruses cause disease?
pdf YouTube
4/23 Lecture 22: Emerging viruses Flint Vol II Chapter 10 pp 333-end
•Heartland virus disease
•
The zoonotic pool
pdf YouTube
4/28 Lecture 23: Unusual infectious agents Flint Vol II Appendix A
•Virophages engineer the ecosystem
pdf YouTube
4/30 Lecture 24: HIV pathogenesis Flint Vol II Chapter 6
•The HIV hideout (podcast)
pdf YouTube
5/5 Lecture 25: H5N1 •Asymptomatic H5N1 infection
•
A bad day for science
pdf YouTube
5/12 Exam III

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by Vincent Racaniello

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Contents

Table of Contents
ME/CFS
Inside a BSL-4
The Wall of Polio
Microbe Art
Interviews With Virologists

Earth’s Virology Course

Virology Live
Columbia U
Virologia en Español
Virology 101
Influenza 101

Podcasts

This Week in Virology
This Week in Microbiology
This Week in Parasitism
This Week in Evolution
Immune
This Week in Neuroscience
All at MicrobeTV

Useful Resources

Lecturio Online Courses
HealthMap
Polio eradication
Promed-Mail
Small Things Considered
ViralZone
Virus Particle Explorer
The Living River
Parasites Without Borders

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