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Virology – Biology W3310/4310
Spring 2014
This Columbia University virology course is offered each year in the spring semester.
Lecture Schedule, Spring 2014
| Date | Topic | Reading | Slides | Videocast | |||
|---|---|---|---|---|---|---|---|
| 1/22 | Lecture 1: What is a virus? | Flint Vol I Chp 1 •The virus and the virion •Cell size and scale •Pandoravirus |
YouTube | ||||
| 1/27 | Lecture 2: The infectious cycle | Flint Vol I Chp 2 •Influenza virus growth in eggs •Influenza hemagglutination inhibition assay •The amazing cells of Henrietta Lacks •The Wall of Polio •Small fragments of viral nucleic acid |
YouTube | ||||
| 1/29 | Lecture 3: Genomes and genetics | Flint Vol I Chp 3 •The Baltimore scheme |
YouTube | ||||
| 2/3 | Lecture 4: Structure | Flint Vol I Chp 4 •Structure of influenza virus •Virus images at ViperDB |
YouTube | ||||
| 2/5 | Lecture 5: Attachment and entry | Flint Vol I Chp 5 •Influenza virus attachment to cells •Influenza virus attachment to cells: Role of different sialic acids •A single amino acid change switches avian influenza H5n1 and H7N9 viruses to human receptors |
YouTube | ||||
| 2/10 | Lecture 6: RNA directed RNA synthesis | Flint Vol I Chp 6 •Influenza viral RNA synthesis •The error prone ways of RNA synthesis |
YouTube | ||||
| 2/12 | Lecture 7: Viral DNA replication | Flint Vol I Chp 9 | YouTube | ||||
| 2/17 | Exam I | ||||||
| 2/19 | Lecture 8: Transcription and RNA processing | Flint Vol I Chp 8 and 10 | YouTube | ||||
| 2/24 | Lecture 9: Reverse transcription and integration | Flint Vol I Chp 7 •Museum pelts help date the Koala retrovirus •Unexpected endogenous retroviruses |
YouTube | ||||
| 2/26 | Lecture 10: Translation | Flint Vol I Chp 11 | YouTube | ||||
| 3/3 | Lecture 11: Assembly | Flint Vol I Chapters 12 and 13 •Packaging of the segmented influenza virus genome |
YouTube | ||||
| 3/5 | Lecture 12: Infection basics | Flint Vol II Chapters 1 and 2 •Transmission of influenza •Slow motion sneezing •Chikungunya an exotic virus on the move •Do the tropics have a flu season? |
YouTube | ||||
| 3/10 | Lecture 13: Intrinsic and innate defenses | Flint Vol II Chapters 3 and 4 •The inflammatory response •Natural antibody protects against viral infection |
YouTube | ||||
| 3/12 | Lecture 14: Adaptive immunity | Flint Vol II Chapter 4 | YouTube | ||||
| 3/17 | Spring Recess | ||||||
| 3/19 | Spring Recess | ||||||
| 3/24 | Lecture 15: Viral virulence | Flint Vol II Chapter 2 •Antimicrobial peptides induced by herpesvirus enhance HIV-1 infection •HIV gets the zinc finger |
YouTube | ||||
| 3/26 | Lecture 16: Acute infections | Flint Vol II Chapter 5 •Acute viral infections •Chronology of an acute infection |
YouTube | ||||
| 3/31 | Lecture 17: Persistent infections | Flint Vol II Chapter 5 | YouTube | ||||
| 4/2 | Exam II | ||||||
| 4/7 | Lecture 18: Transformation and oncogenesis | Flint Vol II Chapter 7 | YouTube | ||||
| 4/9 | Lecture 19: Vaccines | Flint Vol II Chapter 8 •Influenza virus-like particle vaccine •Poliovirus vaccine safety |
YouTube | ||||
| 4/14 | Lecture 20: Antivirals | Flint Vol II Chapter 9 •Treating hepatitis C by blocking a cellular microRNA •TWiV 270: Homeland virology (developing a smallpox antiviral) |
YouTube | ||||
| 4/16 | Lecture 21: Evolution | Flint Vol II Chapter 10 pp 311-333 •Virulence – a positive or negative trait for evolution? •Increased fidelity reduces viral fitness •Why do viruses cause disease? |
YouTube | ||||
| 4/23 | Lecture 22: Emerging viruses | Flint Vol II Chapter 10 pp 333-end •Heartland virus disease •The zoonotic pool |
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| 4/28 | Lecture 23: Unusual infectious agents | Flint Vol II Appendix A •Virophages engineer the ecosystem |
YouTube | ||||
| 4/30 | Lecture 24: HIV pathogenesis | Flint Vol II Chapter 6 •The HIV hideout (podcast) |
YouTube | ||||
| 5/5 | Lecture 25: H5N1 | •Asymptomatic H5N1 infection •A bad day for science |
YouTube | ||||
| 5/12 | Exam III | ||||||
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