virology blog
About viruses and viral disease
The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner.
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Download TWiV 535 (58 MB .mp3, 96 min)
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Show notes at microbe.tv/twiv
Intestinal dysmotility disorders such as irritable bowel syndrome affect 10-30% of humans in Western countries. Some of these diseases appear to correlate with viral infection. Inoculation of mice with neurotropic flaviviruses leads to injury and death of enteric neurons, inflammation, intestinal dilation and retarded bowel transit, providing a model for studying and treating these human intestinal disorders. [Read more…] about Viral infections of the enteric nervous system and intestinal dysmotility
By Gertrud U. Rey
Zika virus (ZIKV) infection causes microcephaly in newborns and is causally associated with Guillian-Barré syndrome in adults. To date, there are no drugs available to prevent or treat ZIKV infection. ZIKV vaccine research is challenging because adult immunocompetent mice are resistant to ZIKV infection and disease.
[Read more…] about A Mouse Model System for Zika Virus Infection
Amy Rosenfeld joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures.
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Download TWiV 468 (66 MB .mp3, 107 min)
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Show notes at microbe.tv/twiv