virology blog
About viruses and viral disease
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine.
Click arrow to play
Download TWiV 832 (77 MB .mp3, 128 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email
Show notes at microbe.tv/twiv
From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses.
Click arrow to play
Download TWiV 643 (67 MB .mp3, 112 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiV!
Show notes at microbe.tv/twiv
The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.
Click arrow to play
Download TWiV 515 (60 MB .mp3, 99 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiV!
Show notes at microbe.tv/twiv
The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function:Â the fusion machinery sits at the tips of virions, and binding proteins are at the sides.
Click arrow to play
Download TWiV 507 (72 MB .mp3, 119 min)
Subscribe (free): iTunes, Google Podcasts, RSS, email
Become a patron of TWiV!
Show notes at microbe.tv/twiv
The membranes of enveloped viruses contain embedded proteins that are essential for attaching to cell receptors and fusing with cell membranes. We generally view these glycoproteins as evenly distributed over the surface of the virus particle, as illustrated for influenza virus. But many more envelope glycoproteins are involved in attachment and entry of larger viruses, and at least for vaccinia virus, they appear to be spatially polarized on virus particles.
[Read more…] about Viral glycoproteins are not always randomly distributed