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vaccinia virus

TWiV 832: Heavy metal flu fighters

21 November 2021 by Vincent Racaniello

TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine.

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Filed Under: This Week in Virology Tagged With: adenovirus vector, adjuvant, correlate of protection, Covaxin, COVID-19, inactivated vaccine, influenza, influenza oral vaccine, mass cytometry, pandemic, SARS-CoV-2, smallpox, vaccine efficacy, vaccinia virus, viral, virology, virus

TWiV 643: Bernie Moss, the real Poxdoc

21 July 2020 by Vincent Racaniello

From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses.

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Filed Under: This Week in Virology Tagged With: mRNA capping, poxvirus, smallpox virus, vaccinia virus, viral, viral vector, virology, virus, viruses

TWiV 515: When virus is in retrograde

14 October 2018 by Vincent Racaniello

The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

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Filed Under: This Week in Virology Tagged With: capsid protein L2, cell penetrating peptide, DRC, ebola virus, HPV, human papillomavirus, outbreak, rabbit skin, respiratory vaccinia, retrograde transport, retromer, Tom Steitz, trans-Golgi network, vaccine, vaccinia virus, viral, virology, virus, virus entry, viruses

TWiV 507: The fusion of form and function

19 August 2018 by Vincent Racaniello

The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.

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Filed Under: This Week in Virology Tagged With: ebola virus, fusion machinery, membrane protein, outbreak, polarized virus proteins, Smithsonian Institution, spillover, super-resolution microscopy, vaccinia virus, viral, virology, virus, viruses, zoonosis

Viral glycoproteins are not always randomly distributed

16 August 2018 by Vincent Racaniello

The membranes of enveloped viruses contain embedded proteins that are essential for attaching to cell receptors and fusing with cell membranes. We generally view these glycoproteins as evenly distributed over the surface of the virus particle, as illustrated for influenza virus. But many more envelope glycoproteins are involved in attachment and entry of larger viruses, and at least for vaccinia virus, they appear to be spatially polarized on virus particles.

[Read more…] about Viral glycoproteins are not always randomly distributed

Filed Under: Basic virology, Information Tagged With: entry fusion complex, polarization and clustering, poxvirus, super-resolution microscopy, vaccinia virus, viral, virology, virus, virus binding, virus fusion, viruses

TWiV 478: A pox on your horse

28 January 2018 by Vincent Racaniello

The TWiV team explains how infectious horsepox virus – likely the ancestor of smallpox vaccines – was recovered from chemically synthesized DNA fragments.

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Filed Under: This Week in Virology Tagged With: dual use research, edward jenner, infectious DNA clone, smallpox, smallpox vaccine, transfection, vaccinia virus, variola, viral, virology, virus, viruses

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

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