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SNIP

TWiV 676: Tragic gene flow from Neanderthals

29 October 2020 by Vincent Racaniello

In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: coronavirus, COVID-19, genome wide association study, GWAS, immunocompromised, immunosuppressed, pandemic, SARS-CoV-2, single nucleotide polymorphism, SNIP, viral, virology, virus

TWiV 671: Prizes, polio, and a pandemic puzzle

12 October 2020 by Vincent Racaniello

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.

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Filed Under: This Week in Virology Tagged With: coronavirus, COVID-19, diagnostic test, inborn errors, interferon, lateral flow assay, pandemic, polio eradication, poliomyelitis, SARS-CoV-2, SNIP, vaccine, viral, virology, virus, viruses

The rarity of paralysis following poliovirus infection

11 September 2019 by Vincent Racaniello

After infection with poliovirus, only about 1% of individuals develop paralysis. I have always wondered whether genetic polymorphisms underlie the rarity of this disease outcome. The results of study carried out in Denmark provide the first insights.

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Filed Under: Basic virology, Information Tagged With: genetic susceptibility, paralysis, poliomyelitis, poliovirus, single nucleotide polymorphism, SNIP, viral, virology, virus, viruses

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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