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TWiV 516: HUSH little virus, don’t you transcribe

21 October 2018 by Vincent Racaniello

Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: chromatin, HIV, human immunodeficiency virus, HUSH complex, LINE-1, promoter, proteasome, provirus, siv, transcriptional repression, viral, virology, virus, viruses, Vpr, Vpx

TWiV 511: Accessory found guilty in DC

16 September 2018 by Vincent Racaniello

Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: AIDS, dendritic cell vaccine, dNTP, HIV-1, hiv-2, human immunodeficiency virus, latent reservoir, myeloid cell, Ned Landau, restriction factor, reverse transcription, SAMHD1, siv, viral, virology, virus, viruses, Vpx

The mystery of lentivirus infection of lemurs

12 September 2018 by Vincent Racaniello

Gray Mouse LemurLemurs are primates found only on the island of Madagascar and a few small neighboring islands. Some of these animals have endogenous lentiviruses in their genomes. How did these viruses infect the isolated lemurs?

[Read more…] about The mystery of lentivirus infection of lemurs

Filed Under: Information, Uncategorized Tagged With: endogenous retrovirus, HIV-1, lemur, lentivirus, Madagascar, siv, viral, virology, virus, viruses

TWiV 409: A Nef is enough

2 October 2016 by Vincent Racaniello

Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.

You can find TWiV #409 at microbe.tv/twiv, or listen below.

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Filed Under: This Week in Virology Tagged With: AIDS, endocytosis, HIV, Nef, restriction factor, SERINC, siv, viral, virion, virology, virus, viruses

TWiV 408: Boston Quammens

25 September 2016 by Vincent Racaniello

Four years after filming ‘Threading the NEIDL’, Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.

You can find TWiV #408 at microbe.tv/twiv, or watch/listen here.

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Filed Under: This Week in Virology Tagged With: AIDS, chimp, David Quammens, ebola virus, HIV, science writing, siv, spillover, viral, virology, virus, viruses, zika virus, zoonosis

TWiV #356: Got viruses?

27 September 2015 by Vincent Racaniello

On episode #356 of the science show This Week in Virology, Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine.

You can find TWiV #356 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: adjuvant, baculovirus, bracovirus, caterpillar, chemokine, Cortesia congregata, DNA, dna vaccine, gut virome, horizontal gene transfer, IgA, in vivo electroporation, kwashiorkor, lepidoptera, Malawi, malnutrition, marasmus, mucosal immunity, nudivirus, parasitic wasp, ready to use therapeutic food, rutf, simian immunodeficiency virus, siv, viral, virology, virus

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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