SARS-CoV-2 not only infects humans but can also spread occasionally from humans to cats, dogs, and tigers. A recent addition to this menagerie is the farmed mink. In mid-April 2020 mink on two farms in the Netherlands developed signs of respiratory disease which included nasal discharge and respiratory distress. Examination of the lungs revealed interstitial …
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Click arrow to playDownload TWiV 624 (74 MB .mp3, 123 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
by Gertrud U. Rey Does a first infection with SARS-CoV-2 make a person immune to a second infection? This question is one of the prevailing issues in the current pandemic. The relevant immune response is adaptive immunity, which initiates during a first exposure to a pathogen and protects from re-infection and disease upon a second …
Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Click arrow to playDownload TWiV 623 (41 MB .mp3, 68 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes …
TWiV 623: Bats and coronaviruses with Peter Daszak Read More »
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and a vaccine candidate. Click arrow to playDownload TWiV 622 (41 MB .mp3, 68 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Small animal models (mice, ferrets, hamsters) are essential for understanding how SARS-CoV-2 causes disease and for pre-clinical evaluation of vaccines and antiviral therapeutics. One promising model has been developed by modifying SARS-CoV-2 so that it binds to murine ACE2. Laboratory mice cannot be infected with SARS-CoV-2 because the viral spike glycoprotein (illustrated) does not bind …
