An important question about the retrovirus XMRV, which has been implicated in prostate cancer and chronic fatigue syndrome, is where the virus replicates in humans. Such information would provide clues about how infection might be transmitted. To date the virus has been detected in malignant prostate cells and in the peripheral blood mononuclear cells and …
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution located in the eponymous town on Long Island, New York. Over 400 scientists work there on a wide range of biological problems, including cancer, neurobiology, plant genetics, and genomics. CSHL has a storied research history, having hosted nine Nobel Laureates. But it is also well …
All mammalian genomes contain genes encoding Apobec proteins. Several members of this protein family (the name stands for apolipoprotein B mRNA editing complex) are induced by interferon and are intrinsic antiretroviral proteins. Apobec proteins inhibit the replication of XMRV, a new human retrovirus associated with prostate cancer and chronic fatigue syndrome. During retroviral replication, Apobec …
Inhibition of XMRV by a weapon of mass deamination Read More »
Hosts: Vincent Racaniello and Stephen Goff Vincent speaks with Stephen Goff about the origin of the retrovirus XMRV and its association with prostate cancer and chronic fatigue syndrome. This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $75-$500 off a Drobo. Win a free Drobo S! Contest rules here. …
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Vincent, Dickson, Alan, and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, …
The suggestion that the retrovirus XMRV is the etiologic agent of chronic fatigue syndrome (CFS) arose from a study in which the virus was found in 68 of 101 US patients. The virus was not detected in two independent studies of 186 and 170 CFS patients in the United Kingdom. A new Dutch study has also …
XMRV not detected in Dutch chronic fatigue patients Read More »
