Most contemporary virologists use the term replication to indicate either the production of new virus particles or viral genomes. Because these are very different processes, during the preparation of the fourth edition of the textbook Principles of Virology, the authors decided to use the word reproduction to designate the production of new infectious virus particles, and replication when referring to nucleic acid synthesis. Recently I learned from Bill Summers, speaking at ASV 2019, how the historical use of these two words reflects our evolving concept of virus.