Various SARS-CoV-2 like viruses have been isolated from bats in China, Thailand, and Japan, but none have a spike protein that can bind ACE2 and allow entry into human cells. Sampling of bats in Laos has now revealed the presence of such viruses. The genome of a virus called RaTG13, from Rhinolophus affinis bats in …
Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain. Click arrow to playDownload TWiEVO 57 (50 MB .mp3, 84 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Show notes at microbe.tv/twievo
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Click arrow to …
TWiV 588: Coronavirus update – Save the pangolin! Read More »
A coronavirus related to SARS-CoV-2 has been isolated from Malayan pangolins illegally imported into Guangdong province. It is not the precursor of SARS-CoV-2, but comparison of viral genome sequences provides further evidence that the virus currently infecting humans was not produced in a laboratory. There are two important sequences in the viral spike glycoprotein (pictured) …
Pangolins and the origin of SARS-CoV-2 coronavirus Read More »
