post-exertional malaise

Trial By Error: In Protocol for Long COVID Exercise Trial, Investigators Advocate Lying to Participants

By David Tuller, DrPH Researchers are planning yet another trial of a rehabilitative exercise program for Long COVID—but, in this one, they propose to lie to all the participants about the nature of the study and the intervention being investigated. BMJ Open has recently published a paper called “Pursuing Reduction in Fatigue After COVID-19 via …

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Trial By Error: Lancet Paper Claims “Exercise” Should be “Prioritized” in Long COVID Rehabilitation

By David Tuller, DrPH Added: On X, @mecfsskeptic has posted a very useful thread explaining how loosely the investigators applied the meaning of “Long COVID” in accepting trials for their meta-analysis. ********** A Lancet journal, eClinicalMedicine, has just published a paper called “Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials.” …

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Trial By Error: Interview with Dr Rob Wüst about New Study of Muscle Abnormalities in Long Covid

By David Tuller, DrPH In early January, Nature Communications published a Dutch study called “Muscle abnormalities worsen after post-exertional malaise in long COVID.” The study caused a buzz among patients, clinicians, and other researchers and generated extensive news coverage. Called. (I wrote a blog post about it here.) The investigators identified significant biological differences after …

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Trial By Error: An Interview With Mt Sinai’s David Putrino About Long Covid, ME/CFS, and Related Issues

By David Tuller, DrPH David Putrino is a neuroscientist and physical therapist at Mt. Sinai Hospital in New York. (Clarification: He trained as a physical therapist in Australia and is not licensed to practice in New York.) He runs a research lab and a rehabilitation center that quickly became a magnet for patients grappling with …

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Trial By Error: More on the REGAIN Trial for Long Covid Patients

By David Tuller, DrPH *April is crowdfunding month at UC Berkeley. If you like my work, consider making a tax-deductible donation to Berkeley’s School of Public Health to support the Trial By Error project: https://crowdfund.berkeley.edu/project/31347********** I wrote recently about the problematic REGAIN study from the University of Warwick, which is testing an exercise-and-psychological-rehab program as …

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