Virologist Vincent Racaniello breaks down the first case of polio in the US in nearly a decade.
poliomyelitis
TWiV 671: Prizes, polio, and a pandemic puzzle
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.
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Download TWiV 671 (102 MB .mp3, 170 min)
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Show notes at microbe.tv/twiv
TWiV 570: Aarhus viral
At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS.
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Download TWiV 570 (61 MB .mp3, 101 min)
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Show notes at microbe.tv/twiv
Polio returns to the Philippines
Cases of poliomyelitis have been reported in the Philippines 19 years after the country was declared free of the disease. The return of poliomyelitis to the country emphasizes the need to maintain high levels of immunization while polioviruses continue to circulate.
The rarity of paralysis following poliovirus infection
After infection with poliovirus, only about 1% of individuals develop paralysis. I have always wondered whether genetic polymorphisms underlie the rarity of this disease outcome. The results of study carried out in Denmark provide the first insights.
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TWiV 373: The distinguished virology career of Julius S. Youngner
On episode #373 of the science show This Week in Virology, Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine.
You can find TWiV #373 at microbe.tv/twiv. Or you can watch the video below.