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TWiV 112: Creating a killer poxvirus

19 December 2010 by Vincent Racaniello

dickson despommierHosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode #112 of the podcast This Week in Virology, Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes.

[powerpress url=”http://traffic.libsyn.com/twiv/TWiV112.mp3″]

Click the arrow above to play, or right-click to download TWiV #112(71 MB .mp3, 98 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

  • Expression of IL-4 makes a killer poxvirus
  • Additional studies on poxvirus-IL-4 recombinants
  • Creation of killer poxvirus could have been predicted
  • Interleukin regulation of Th responses
  • Severe pandemic H1N1 disease due to immune complexes
  • Unusually high influenza mortality in 18-65 years old
  • The complement system
  • TWiV on Facebook
  • Letters read on TWiV 112

Weekly Science Picks

Rich – The Scientist’s Top 10 Innovations 2010
Alan – Avian Vocalizations Center
Vincent – Microbial soap from Cleaner Science (thanks, Nadia!)

Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Filed Under: This Week in Virology Tagged With: bioterrorism, complement, ectromelia, H1N1, influenza, pandemic, podcast. twiv, poxvirus, smallpox, vaccinia, viral, virology, virus

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

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Gertrud U. Rey

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