Shortly after Félix d’Herelle discovered viruses that infect bacteria in 1917 (also found in 1915 by Twort), he recognized their therapeutic potential for treating infections. The discovery of penicillin in 1928 began the golden age of antibiotics, which pushed aside progress in treating infections with bacteriophages. With the advent of widespread antimicrobial resistance, development of phages as therapeutic drugs gained momentum. Three recent examples serve to illustrate the untapped potential of these viruses for treating human bacterial infections.