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organ transplant

Fatal yellow fever in a transplant recipient

23 May 2019 by Vincent Racaniello

FlavivirusInfection with yellow fever virus caused the death of a patient 25 years after receiving a kidney transplant, illustrating the difficulties associated with some medical vaccine exemptions.

The patient had received a kidney transplant at the age of 58 in February 1993. Nearly 25 years later he was admitted to hospital with two days of fever, nausea, and vomiting. A sonogram revealed an enlarged right lobe of the liver, but tests for hepatitis A, B, C and HIV-1 were negative. He progressed to hepatic insufficiency and acute liver failure and died 6 days after admission to hospital.

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Filed Under: Basic virology, Information Tagged With: hepatic failure, immunosuppression, medical vaccine exemption, organ transplant, viral, virology, virus, viruses, yellow fever vaccine, yellow fever virus

TWiV 455: Pork and genes

20 August 2017 by Vincent Racaniello

Erin Garcia joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.

 

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: computer security, CRISPR/Cas9, DNA based exploit, IFIH1, loss of function, MDA5, organ transplant, PERV, PERV free pig, porcine endogenous retrovirus, remote code execution, respiratory syncytial virus, rhinovirus, severe viral respiratory infection, viral, virology, virus

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by Vincent Racaniello

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