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About viruses and viral disease

NPC1

TWiV 415: Ebola pipettors and the philosopher’s clone

13 November 2016 by Vincent Racaniello

Jeremy Luban, Aaron Lin, and Ted Diehl join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.

You can find TWiV #415 at microbe.tv/twiv, or listen below.

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Filed Under: This Week in Virology Tagged With: adaptation, amino acid, ebola virus, filovirus, glycoprotein, mutation, NPC1, spillover, viral, virology, virus, viruses, zoonosis

TWiEVO 5: Looking at straw colored fruit bats through a straw

20 February 2016 by Vincent Racaniello

TWiEVOOn episode #5 of the science show This Week in Evolution, Sara Sawyer and Kartik Chandran join Nels and Vincent to talk about how the filovirus receptor NPC1 regulates Ebolavirus susceptibility in bats.

You can find TWiEVO #5 at microbe.tv/twievo, or you can listen below.

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Filed Under: This Week in Evolution Tagged With: bat, ebolavirus, filovirus, host-virus conflict, NPC1, positive selection, receptor, viral, virology, virus, virus entry, viruses

TWiV 314: Einstein goes viral

7 December 2014 by Vincent Racaniello

On episode #314 of the science show This Week in Virology, Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.

You can find TWiV #314 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: CDC protein, checkpoint, cholesterol, ebola virus, Ebolaviruses, endosome, hemorrhagic fever, HIV-1, INI1, integrase, lysosome, membrane fusion, monoclonal antibody, NPC1, rhabdoid tumor, tumor suppressor, viral, virology, virus, virus entry

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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Inside a BSL-4
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