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TWiV 984: Clinical update with Dr. Daniel Griffin

18 February 2023 by Vincent Racaniello

In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: antiviral, coronavirus, COVID-19, delta, inflammation, influenza, Long Covid, monkeypox, monoclonal antibody, Omicron, pandemic, poliovirus, SARS-CoV-2, vaccine, vaccine booster, variant of concern, viral, virology, virus, viruses

TWiV 953: Clinical update with Dr. Daniel Griffin

12 November 2022 by Vincent Racaniello

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19,  protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: antiviral, coronavirus, COVID-19, delta, inflammation, Long Covid, marburg virus, monkeypox, monoclonal antibody, Omicron, pandemic, poliovirus, SARS-CoV-2, vaccine, vaccine booster, variant of concern, viral, virology, virus, viruses

Jake Scott put the ID in COVID-19

6 November 2022 by Vincent Racaniello

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler

Guest: Jake Scott

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Filed Under: This Week in Virology Tagged With: coronavirus, COVID-19, monoclonal antibody, Omicron, pandemic, Paxlovid, SARS-CoV-2, viral, virology, virus, viruses

TWiV 951: Clinical update with Dr. Daniel Griffin

5 November 2022 by Vincent Racaniello

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: antiviral, coronavirus, COVID-19, delta, inflammation, influenza, Long Covid, marburg virus, monkeypox, monoclonal antibody, Omicron, pandemic, poliovirus, SARS-CoV-2, vaccine, vaccine booster, variant of concern, viral, virology, virus, viruses

TWiV 949: Clinical update with Dr. Daniel Griffin

29 October 2022 by Vincent Racaniello

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: antiviral, coronavirus, COVID-19, delta, inflammation, influenza, Long Covid, marburg virus, monkeypox, monoclonal antibody, Omicron, pandemic, poliovirus, SARS-CoV-2, vaccine, vaccine booster, variant of concern, viral, virology, virus, viruses

TWiV 947: Clinical update with Dr. Daniel Griffin

22 October 2022 by Vincent Racaniello

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: antiviral, coronavirus, COVID-19, delta, inflammation, influenza, Long Covid, marburg virus, monkeypox, monoclonal antibody, Omicron, pandemic, poliovirus, SARS-CoV-2, vaccine, vaccine booster, variant of concern, viral, virology, virus, viruses

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by Vincent Racaniello

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