Although we are less than a year into the SARS-CoV-2 pandemic, it appears that the antibodies induced by infection are often of poor quality, and B cell memory seems limited. An explanation for this outcome might be a consequence of the loss of germinal centers in COVID-19 patients. Examination of lymph nodes and spleen of …
Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph is circadian – it is dependent on the time of day. <span data-mce-type=”bookmark” class=”mce_SELRES_start”></span> Click arrow to play Download Immune 2 (53 MB .mp3, 87 min) Subscribe (free): iTunes, RSS, email Become a patron of Immune! Show notes at microbe.tv/immune
When you are infected with a microbe, pieces of the pathogen are picked up by sentinel dendritic cells and brought to local lymph nodes. There the sentinels present their gifts to lymphocytes – B (pictured; image credit) and T cells – who then decide if they are foreign, in which case an immune response begins. …
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Gabriel Victora Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes. Please help us by taking our listener survey. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV161.mp3″] Click the arrow above to play, or right-click to download …
