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TWiV 307: Ebola aetiology

19 October 2014 by Vincent Racaniello

On episode #307 of the science show This Week in Virology, Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more.

You can find TWiV #307 at www.microbe.tv/twiv.

Filed Under: Basic virology, Information Tagged With: aerosol, air travel, airborne, antiviral drug, Dallas patient, dog, Ebola, ebolavirus, fever detector, fomite, Guinea, hemorrhagic fever, infectivity, Liberia, Sierra Leone, transmission, viral, virology, virus, West Africa

TWiV 306: This Week in Ebolavirus

12 October 2014 by Vincent Racaniello

On episode #306 of the science show This Week in Virology, the Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs.

You can find TWiV #306 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: aerosol, air travel, airborne, antiviral drug, Dallas patient, dog, Ebola, ebolavirus, fever detector, fomite, Guinea, hemorrhagic fever, infectivity, Liberia, Sierra Leone, transmission, viral, virology, virus, West Africa

TWiV 305: Rhymes with shinola

5 October 2014 by Vincent Racaniello

On episode #305 of the science show This Week in Virology, Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.

You can find TWiV #305 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: ebola virus, ebolavirus, enterovirus, epidemic, EV-D68, Guinea, Liberia, polio-like paralysis, reproductive index, Sierra Leone, Tagged as: case fatality ratio, transmission, viral, virology, virus, Zaire

Ebola virus enters the United States

2 October 2014 by Vincent Racaniello

Filovirus virion
Image credit: ViralZone

Given the extent of the Ebola virus outbreak in West Africa, transport of an infected individual to the US was bound to happen. The case is an adult who had contact with an Ebola virus-infected woman in Liberia, then traveled to Dallas. He had no symptoms before arriving in the US and therefore did not likely transmit the infection to airplane passengers. He sought medical care on 26 Sep 2014 and was admitted to Texas Health Presbyterian Hospital 28 Sep 2014 where he is currently under isolation. Samples sent to the CDC tested positive for Ebola virus. There are excellent summaries of the events at ProMedMail and the CDC website.

Apparently the Dallas patient told a healthcare worker during his first hospital visit that he had been in Liberia. This information was not transmitted to his physician. The word ‘Liberia’ should have set off alarm bells. Furthermore, if the physician did not receive the patient’s recent travel history, he/she should have requested it. There is no room for error when dealing with Ebola virus infection.

It is puzzling that travel (excluding healthcare workers) out of the affected West African countries is still permitted. As moderator JW notes on ProMedMail: “This chain of events illustrates the danger that anybody arriving from Liberia, even without symptoms on departure from there or on arrival in the USA (or anywhere else in Africa or overseas) may be incubating Ebola — but not international volunteers who have only been in contact with Liberians while wearing adequate PPE (personal protection equipment).”

Why is it important to stop travel out of the affected countries? While I’m confident that the US can detect and properly contain imported Ebola virus infections, not all countries will be able to do so. There are dozens of other countries that are unprepared to deal with an infected case, from diagnosis to isolation to treatment. I can easily imagine infection quickly getting out of control in such countries: millions are at risk. While the economics of stopping air travel out of Liberia, Sierra Leone, and Guinea will be severe, they cannot approach the devastation of having outbreaks burning simultaneously in multiple countries.

Update: NPR has a good explanation of the reproductive index, or the number of persons who can be infected by another infected person during an outbreak. For Ebola virus, this number is 1-2. This low number is why quarantine can be effective.

Filed Under: Events, Information Tagged With: Dallas, ebola virus, ebolavirus, epidemic, hemorrhagic fever, imported case, Liberia, viral, virology, virus

TWiV 298: MV-NIS de myelo

17 August 2014 by Vincent Racaniello

On episode #298 of the science show This Week in Virology, the TWiV gang answers follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of  disseminated multiple myeloma with oncolytic measles virus.

You can find TWiV #298 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: antiviral, Ebola, Guinea, hemorrhagic fever, Liberia, measles virus, multiple myeloma, oncolytic, oncotherapy, Sierra Leone, vaccine, viral, virology, virus

TWiV 297: Ebola! Don’t panic

10 August 2014 by Vincent Racaniello

On episode #297 of the science show This Week in Virology, the TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline.

You can find TWiV #297 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: antiviral, Ebola, ebolavirus, filovirus, Guinea, hemorrhagic fever, Liberia, Reston, Sierra Leone, vaccine, viral, virology, virus, Zaire

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by Vincent Racaniello

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