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About viruses and viral disease

latent reservoir

CRISPR-ing HIV-1

20 September 2018 by Gertrud U. Rey

HIV-1 genomeBy Gertrud U. Rey

Although antiretroviral therapy (ART) has been highly effective at controlling HIV-1 viral loads in the bloodstream of infected individuals, the virus remains latent in infected cells and starts replicating within a couple of weeks upon termination of therapy.

[Read more…] about CRISPR-ing HIV-1

Filed Under: Gertrud Rey Tagged With: CRISPR-Cas9, gene therapy, HIV-1, latent reservoir, lentivirus, provirus excision, vector, viral, virology, virus, viruses

TWiV 511: Accessory found guilty in DC

16 September 2018 by Vincent Racaniello

Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.

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Filed Under: This Week in Virology Tagged With: AIDS, dendritic cell vaccine, dNTP, HIV-1, hiv-2, human immunodeficiency virus, latent reservoir, myeloid cell, Ned Landau, restriction factor, reverse transcription, SAMHD1, siv, viral, virology, virus, viruses, Vpx

TWiV 510: Retroviruses at Cold Spring Harbor

9 September 2018 by Vincent Racaniello

Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.

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Filed Under: This Week in Virology Tagged With: AIDS, CG dinucleotide suppression, cold spring harbor, DNA tumor virus, HIV-1, latent reservoir, retrovirus, rna tumor virus, viral, virology, virus, ZAP

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