By David Tuller, DrPH
[*In the last paragraph, I mistakenly referred to the CODES protocol rather than the CODES statistical analysis plan. I apologize for the error.]
I have recently written about CODES, the high-profile clinical trial investigating whether cognitive behavior therapy (CBT) could reduce the frequency of dissociative seizures, also known as psychogenic non-epileptic seizures. The trial, published by Lancet Psychiatry, was an open-label study relying on self-reported outcomes–a design highly vulnerable to bias. The 368 participants were randomized into two arms—a group that received standardized medical care (SMC) along with a form of CBT designed to impart seizure-reduction strategies, and a group that received SMC alone.
[Read more…] about Trial By Error: More Questions About CODES Trial of CBT for Seizures