When a human population is exposed to a pathogenic virus, the outcomes among individuals may include asymptomatic, mild, severe, or no infection. Multiple parameters control these responses, including the amount of virus taken up, the age of the host, general health status, nutrition, and more. With the advent of whole exome sequencing we can now assess the role of genotype in disease severity, as illustrated by a study of a child with severe recurrent rhinovirus infections.
Erin Garcia joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.
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Show notes at microbe.tv/twiv