herpesvirus

A Viral Heist

HSV-1 virions capture the cellular motor protein kinesin from initially infected epithelial cells and ferry it to subsequently infected neuronal cells to deliver their genome into the nucleus of those cells.

TWiV 833: Grand theft kinesin

TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles. Click arrow to playDownload TWiV 833 (77 MB .mp3, 128 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv

CRISPR-ing herpes simplex virus

by Gertrud U. Rey Herpes simplex viruses establish lifelong persistent infection in sensory neurons of infected individuals, a phenomenon called latency. Latent viral genomes are “dormant” but can sporadically reactivate and begin replicating in a phase called lytic replication, which is often accompanied by shedding of virus particles and the appearance of painful lesions. There …

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TWiV 579: Reno viral

Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Click arrow to play Download TWiV 579 (61 MB .mp3, 101 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

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