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TWiV 524: Slicing and dicing with Raul

12 December 2018 by Vincent Racaniello

Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: argonaute, cricket, dicer, drosophila, insect, proteasome, RNA interference, rnai, ubiquitin, viral, virology, virus, viruses

TWiV 477: Raiders of the lost Arc

21 January 2018 by Vincent Racaniello

The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA within vesicles across the synapse.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: Arc, darc, drosophila, exovesicles, gag, jumping genes, neuron, retrotransposon, retrovirus, synapse, transposable element, viral, virology, virus, virus-like particle, viruses

TWiV 348: Chicken shift

2 August 2015 by Vincent Racaniello

On episode #348 of the science show This Week in Virology, Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek’s disease viral vaccine that allows transmission of virulent viruses.

You can find TWiV #348 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: drosophila, evolution, fruit fly, herpesvirus, Marek's disease, nigeria, permissive vaccine, polio, polio eradication, poliomyelitis, selection, transmission, vaccine, viral, virology, virulence, virus

TWiV 138: RISCy business with Raul Andino

19 June 2011 by Vincent Racaniello

Drosophila melanogasterHosts: Vincent Racaniello and Raul Andino

Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.

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Links for this episode:

  • Antiviral immunity in Drosophila requires RNAi spread (Nature)
  • Cricket paralysis virus antagonizes Argonaute 2 in Drosophila (Nature Struct Biol)
  • Dicistroviridae at ViralZone
  • TWiV on Facebook

Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Filed Under: This Week in Virology Tagged With: argonaute, dicer, drosophila, fly, immunity, innate immunity, raul andino, risc, RNA interference, siRNA, viral, virology, virus

TWiV 61: Original antigenic sin

6 December 2009 by Vincent Racaniello

TWiV_AA_200Hosts: Vincent Racaniello and Dickson Despommier

On episode 61 of the podcast “This Week in Virology”, Vincent and Dick muse about the symbiotic bacterium, Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.

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Click the arrow above to play, or right-click to download TWiV #61 (45 MB .mp3, 62 minutes)

Subscribe to TWiV in iTunes, by the RSS feed, or by email

Links for this episode:

  • Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans
  • Wolbachia induces resistance to RNA virus infections in Drosophila
  • Wolbachia reduces blood-feeding success in Dengue mosquito
  • Did 2009 H1N1 influenza come from a laboratory?
  • Influenza original antigenic sin in mice but not in humans
  • Dengue outbreak in Mexico (thanks Swiss compass!)
  • Pig at Minnesota state fair infected with 2009 H1N1 (thanks Swiss compass!)
  • Baby kissing pig (jpg) (thanks Swiss compass!)

Weekly Science Picks
Dick New Guinea Tapeworms and Jewish Grandmothers by Robert S. Desowitz
Vincent
Information is Beautiful – is swine flu vaccine safe?

Send your virology questions and comments (email or mp3 file) to twiv@microbe.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Filed Under: This Week in Virology Tagged With: Dengue, drosophila, H1N1, influenza, mosquito, original antigenic sin, swine flu, symbiont, viral, virology, virus, wolbachia

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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