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virology blog

About viruses and viral disease

DNA sensor

TWiV 570: Aarhus viral

20 October 2019 by Vincent Racaniello

At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: Aarhus University, AIDS, AIDS cure, cGAS, DNA sensor, herpes simplex virus, HIV-1, HIV-1 latent reservoir, host genetics, polIII, polio, poliomyelitis, poliovirus, STING, TLR9, varicella-zoster virus, viral, virology, virus, viruses

TWiV 484: Float like a mimivirus STING like a bat

11 March 2018 by Vincent Racaniello

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.

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Filed Under: This Week in Virology Tagged With: aaRS, bat, cGAMP, cGAS, DNA sensor, IFN, interferon, irf3, mimivirus, phosphorylation, positive selection, ribosome, STING, tailed capsid, Tupanvirus, viral, virology, virus, viruses

TWiV 456: Be careful of canons

27 August 2017 by Vincent Racaniello

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

 

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Download TWiV 456 (75 MB .mp3, 124 min)
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Show notes at microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: 5'-triphosphate, cGAMP, cGAS, dengue virus, DNA sensor, inborn error, innate immunity, mitochondria, RNA polymerase III, STING, varicella, varicella-zoster virus, viral, virology, virus, viruses, VZV

TWiV 358: Virology and proteomics with Ileana Cristea

11 October 2015 by Vincent Racaniello

On episode #358 of the science show This Week in Virology, Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host.

You can find TWiV #358 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: bioinformatics, DNA sensor, herpesvirus, IFI16, Ileana Cristea, innate immunity, mass spectrometry, metabolomics, proteomics, sirtuin, viral, virology, virus

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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