Dengvaxia

A risky vaccine

9 May 2019 by Gertrud U. Rey

by Gertrud U. Rey

Dengue fever, caused by dengue virus (DENV), is of substantial public health significance in the tropics, where the virus is spread by Aedes mosquitoes. Last week the FDA announced its approval of a first vaccine for the prevention of dengue disease in endemic areas.

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Immune 3: Two epitopes, four serotypes, and a partridge in a pear tree

16 December 2017 by Vincent Racaniello

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus.

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TWiV 471: Songs of innocence and experience

10 December 2017 by Vincent Racaniello

The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients.

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Show notes at microbe.tv/twiv

A problem with dengue virus vaccine

7 December 2017 by Vincent Racaniello

A dengue virus vaccine was recently developed not only to prevent first infections, but to avoid severe disease that may occur upon second and third infections. This consequence, called antibody dependent enhancement (ADE), now appears to be caused by the vaccine itself.