Severe dengue virus disease, also known as dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), is most likely to occur in previously infected individuals experiencing a second encounter with a different serotype. A specific range of serum antibody titers has been shown to enhance viral replication in cell culture and in animal models, and now in humans.
[Read more…] about Antibodies mediate severe dengue in humans
A dengue virus vaccine was recently developed not only to prevent first infections, but to avoid severe disease that may occur upon second and third infections. This consequence, called antibody dependent enhancement (ADE), now appears to be caused by the vaccine itself.