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cryoEM

TWiV 534: Portal to the METTL

10 February 2019 by Vincent Racaniello

The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: calicivirus, cryoEM, cytomegalovirus, endocytosis, HCMV, herpesvirus, IFN, ISG, m6A methylation, methyl eraser, methyl reader, methyl writer, METTL, mRNA stability, portal, receptor, uncoating, viral, virology, virus, viruses

TWiV 506: A Cafeteria full of jelly rolls

12 August 2018 by Vincent Racaniello

The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: aedes aegypti, bacteriovore, Cafeteria roenbergensis virus, cryoEM, dengue fever, giant virus, spiral assembly, vaccines, viral, virology, virus, virus structure, viruses, wolbachia

TWiV 463: We haven’t meth but these names ring Nobel

15 October 2017 by Vincent Racaniello

The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: alfalfa mosaic virus, Arabidopsis thaliana, circadian rhythm, clock, cryo-electron microscopy, cryoEM, cucumber mosaic virus, N6-methyladenosine, Nobel Prize, RNA methylation, Seymour Benzer, viral, virology, virus, viruses

TWiV 448: Mavis the Structure Maven

2 July 2017 by Vincent Racaniello

From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy.

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Filed Under: This Week in Virology Tagged With: aav, adeno-associated virus, cryo-electron microscopy, cryoEM, Mavis Agbandje-McKenna, viral, virology, virus, virus structure, virus vector, X-ray crystallography

TWiV 394: Cards in a hand

19 June 2016 by Vincent Racaniello

Vincent and Alan speak with Erica Ollmann Saphire about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.

You can find TWiV #394 at microbe.tv/twiv, or listen or watch the video below.

[powerpress url=”http://traffic.libsyn.com/twiv/TWiV394.mp3″]

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Filed Under: This Week in Virology Tagged With: cryoEM, ebolavirus, filovirus, marburg virus, protein, protein structure, structural biology, viral, virology, virus, viruses, X-ray structure

TWiV 383: A zillion Zika papers and a Brazilian

3 April 2016 by Vincent Racaniello

TWiVEsper Kallas and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle. All on episode #383 of the science show This Week in Virology.

Audio and full show notes for TWiV #383 at microbe.tv/twiv or listen below.

[powerpress url=”http://traffic.libsyn.com/twiv/TWiV383.mp3″]

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Filed Under: This Week in Virology Tagged With: Aedes agepytii, Aedes albopictus, cryoEM, fetus, microcephaly, mosquito, mouse model, saliva, sexual transmission, urine, viral, virology, virus, viruses, Zika, zika virus

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
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