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About viruses and viral disease

cGAMP

TWiV 484: Float like a mimivirus STING like a bat

11 March 2018 by Vincent Racaniello

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: aaRS, bat, cGAMP, cGAS, DNA sensor, IFN, interferon, irf3, mimivirus, phosphorylation, positive selection, ribosome, STING, tailed capsid, Tupanvirus, viral, virology, virus, viruses

TWiV 456: Be careful of canons

27 August 2017 by Vincent Racaniello

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

 

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Show notes at microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: 5'-triphosphate, cGAMP, cGAS, dengue virus, DNA sensor, inborn error, innate immunity, mitochondria, RNA polymerase III, STING, varicella, varicella-zoster virus, viral, virology, virus, viruses, VZV

TWiV 353: STING and the antiviral police

6 September 2015 by Vincent Racaniello

On episode #353 of the science show This Week in Virology, the TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.

You can find TWiV #353 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: agammaglobulinemia, cGAMP, cGAS, IFN, innate immunity, interferon, packaging, poliovirus, Sabin vaccine, shedding, STING, vaccine-derived poliovirus, VDPV, viral, virology, virus, virus particle

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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