virology blog
About viruses and viral disease
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Download TWiV 887 (65 MB .mp3, 108 min)
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Show notes at microbe.tv/twiv
by Gertrud U. Rey
Dengue fever, caused by dengue virus (DENV), is of substantial public health significance in the tropics, where the virus is spread by Aedes mosquitoes. Last week the FDA announced its approval of a first vaccine for the prevention of dengue disease in endemic areas.
The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.
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Severe dengue virus disease, also known as dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), is most likely to occur in previously infected individuals experiencing a second encounter with a different serotype. A specific range of serum antibody titers has been shown to enhance viral replication in cell culture and in animal models, and now in humans.
[Read more…] about Antibodies mediate severe dengue in humans
The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients.
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Download TWiV 471 (66 MB .mp3, 108 min)
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Show notes at microbe.tv/twiv