Risk factors for the chronic neurodegenerative condition known as Alzheimer’s disease (AD) include many cellular genes and pathogenic microbes. Nucleic acids of two ubiquitous human herpesviruses, HHV-6A and HHV-7, have been found at higher levels in AD brains compared with healthy controls, and appear to regulate genes implicated in risk of developing the disease.
Transmissible spongiform encephalopathies (TSEs) are rare, but always fatal, neurodegenerative disorders of humans and other mammals. They are characterized by long incubation periods, spongiform changes in the brain associated with loss of neurons, and the absence of host responses. TSEs are caused by infectious proteins called prions. Insight into how prions cause TSEs comes from the observation that …
Hosts: Vincent Racaniello and Dick Despommier In episode #46 of the podcast “This Week in Virology”, Vincent and Dick continue virology 101 with a discussion of virus entry into cells, then answer reader email on colony collapse disorder and viruses that confer a benefit to their host. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV046.mp3″] Click the arrow above to play, …
