acute infection

Five year persistence of Ebolavirus in humans

The current outbreak of Ebolavirus disease in Guinea, which began in February 2021, may have originated from a survivor of the 2013-16 outbreak in the same country. Phylogenetic analysis of genome sequences revealed that viruses from the current outbreak group with the Makona variant, which caused the 2013-16 epidemic. The new isolates are most closely …

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Antigenic variation explains recurring acute infections

The rapid clearance of acute viral infections is a consequence of robust host defenses. Survivors of acute infections are usually immune to infection with the same virus. If the immune response is so effective, why do some viral infections – such as the common cold or influenza – occur repeatedly? Acute infections recur because selection …

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