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acute flaccid myelitis

TWiV 572: Your EV-D68th nervous breakdown

3 November 2019 by Vincent Racaniello

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: acute flaccid myelitis, AFM, astrocytes, cerebrospinal fluid, CSF, enterovirus D68, neurons, neurotropic, poliovirus, serology, viral, virology, virus, viruses

Neurotropism of enterovirus D68 is not a recently acquired property

24 October 2019 by Vincent Racaniello

EV-D68with Amy Rosenfeld

Enterovirus D68 (EV-D68) was first isolated from children with respiratory disease in 1962. No outbreaks of infection were detected until the late summer and early fall of 2014, and then in 2016 and 2018. During these epidemics of respiratory disease, some children developed polio-like paralysis. We have recently published a paper showing that isolates of EV-D68 from 1962 through 2014 are capable of infecting cells of the nervous system, disproving the hypothesis that neurotropism of the virus is a recently acquired phenotype.

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Filed Under: Basic virology, Information Tagged With: acute flaccid myelitis, astrocyte, childhood paralysis, enterovirus D68, neuron, neurotropism, poliovirus, viral, virology, virus, viruses

TWiV 568: Karolinska viral

6 October 2019 by Vincent Racaniello

In the second episode from the Karolinska Institute in Stockholm, Vincent speaks with Jan Albert, Petter Brodin, and Anna Smed-Sörensen about their work on enterovirus D68, systems immunology, and human pulmonary viral infection and inflammation.

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Show notes at microbe.tv/twiv

Filed Under: This Week in Virology Tagged With: acute flaccid myelitis, dendritic cell, enterovirus D68, epidemiology, hantavirus, influenza virus, maternal antibodies, mononuclear phagocyte, newborn anti-viral antibodies, placenta, respiratory viral infection, systems immunology, viral, virology, virus, viruses

TWiV 331: Why is this outbreak different from all other outbreaks?

5 April 2015 by Vincent Racaniello

On episode #331 of the science show This Week in Virology, the TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease.

You can find TWiV #331 at www.microbe.tv/twiv.

Filed Under: This Week in Virology Tagged With: acute flaccid myelitis, acute flaccid paralysis, chronic fatigue syndrome, enterovirus, enterovirus D68, mecfs, neurological disease, paralysis, picornavirus, poliomyelitis, poliovirus, viral, virology, virus

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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