When the 2009 H1N1 pandemic influenza virus emerged earlier this year, I began re-reading John Barry’s The Great Influenza. I came across the sentences that I had underlined during my first read identifying errors in basic virology. Because this is a very popular book, it’s important to identify the mistakes and correct them. Barry is …
One notable characteristic of the four previous influenza pandemics is that they occurred in multiple waves. The 1918 pandemic began with outbreaks of low mortality in the spring and summer, followed by a more lethal wave in the winter. This pattern has fueled speculation that the current H1N1 pandemic strain will undergo mutation that leads …
Here are answers to questions send to virology blog about the new strain of influenza H1N1 that is spreading globally. Q: Regarding this marker (PB1-F2) – is it something that was present as well in the early wave of the 1918 virus, which was also considered mild up until August, or was it something that …
Influenza A/Mexico/2009 (H1N1) – Questions and answers Read More »
The second RNA segment of the influenza virus genome encodes two proteins, PB1 and PB1-F2. The latter protein is believed to be an important determinant of virulence of influenza virus. Can we learn anything about the virulence of the new influenza virus H1N1 strains from a study of this protein? During influenza virus infection, PB1-F2 …
Influenza A/Mexico/2009 (H1N1): Absence of crucial virulence marker Read More »
A new strain of swine influenza virus has been recently isolated from seven persons in the US. Is it time to break out the swine flu vaccine of 1976? Last week the CDC reported that swine influenza virus had been isolated from two children with respiratory illness in California. The cases were not linked and …
