TWiV 984: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during …

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TWiV 975: Crossing the Ts with Daniela Weiskopf

Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Daniela Weiskopf Click arrow to playDownload TWiV 975 (58 MB .mp3, 98 …

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When Two Different Viruses Have Offspring

by Gertrud U. Rey Have you ever wondered what would happen if you were infected with two different viruses at the same time? A recent study aimed at addressing this question has produced some astounding new findings. The authors of the study wanted to observe the interactions between respiratory syncytial virus (RSV) and influenza A …

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TWiV 966: 1918 influenza with Jeffery Taubenberger

Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus.

“Paxlovid Rebound” Is Just COVID Rebound

by Gertrud U. Rey The antiviral drug Paxlovid is highly effective at inhibiting SARS-CoV-2 replication and reducing symptoms associated with COVID-19. Nevertheless, there have recently been numerous reports of recurrence of positive tests and symptoms after completing treatment with Paxlovid, leading some to infer that the drug triggers the recurrence. Is this inference actually correct, …

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TWiV 954: Speculating sarbecovirus spillovers with Michael Letko

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.

Trial By Error: More on the Controversy over Invisible Illness

By David Tuller, DrPH Emily Mendenhall’s new book, Invisible Illness: A History from Hysteria to Long COVID, has caused a bit of an uproar in some circles. Mendenhall, a medical anthropologist at Georgetown University in Washington, D.C., covers a range of what she calls “complex chronic illnesses,” including ME/CFS, fibromyalgia, Lyme disease, and so on. …

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Trial By Error: Some Things I’ve Read Recently…Maryland Boosts LC Research, van der Zee on CBT, Thoughts on Hope and Chronic Illness

By David Tuller, DrPH My rib injury sidelined me for a month. Now that I’m mostly better, I’ve been trying to get back up to speed and catch up with lots of lots of reading (and some viewing). Here are a few items that caught my eye. Maryland seeks to boost Long COVID research, per …

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Trial By Error: New Medical Anthropology Book on Chronic Illness Triggers Controversy

By David Tuller, DrPH While I was on medical leave for the last few weeks, the fascist regime’s brownshirts executed two people protesting the military occupation of Minneapolis. (It seems important to make that point before anything else.) Of course, other stuff has been happening too. In the domain of common interest here, a new …

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Trial By Error: An Essay on Living with Severe ME

By David Tuller, DrPH I’ve been totally out of commission for three weeks while recovering from bruised ribs sustained in a fall. I have devoted most of my time trying to find sitting and lying positions that did not cause excruciating pain. That part is over, and I’m slowly getting back to work and catching …

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Trial By Error: My Unexpected E-Mail Exchange with Alem Matthees

By David Tuller, DrPH In recent months, one of the most high-profile people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—Australian Alem Matthees—has reported significant improvement in his condition. He is still bed-bound, and is still not speaking. This is not, by any means, “recovery.” Nonetheless, the change in Alem’s ability to read, consume information and communicate …

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Trial By Error: Journal Publishes Confusing Section on “Enduring Symptoms”

By David Tuller, DrPH As part of its December issue, Future Healthcare Journal, sponsored by the UK’s Royal College of Physicians, has published a special section called “Challenging Myths: Debunking Functional Disorders.” The special section title itself creates confusion. In what way are functional disorders being “debunked”? I assume the idea is to debunk the …

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