An mRNA Vaccine to Treat Cancer

by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines …

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H5N1 – It’s All About the Transmission

by Gertrud U. Rey Recent news headlines have been highlighting the global spread of H5N1, the strain of influenza virus that is typically associated with “bird flu.” This outbreak is the largest in recorded history, involving at least 50 million dead birds and countless non-human mammals, including sea lions, otters, mink, foxes, cats, dogs, and …

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TWiV 985: Bambi’s revenge

TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Click arrow to playDownload TWiV 985 (66 MB .mp3, 109 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become …

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TWiV 984: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during …

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TWiV 975: Crossing the Ts with Daniela Weiskopf

Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Daniela Weiskopf Click arrow to playDownload TWiV 975 (58 MB .mp3, 98 …

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When Two Different Viruses Have Offspring

by Gertrud U. Rey Have you ever wondered what would happen if you were infected with two different viruses at the same time? A recent study aimed at addressing this question has produced some astounding new findings. The authors of the study wanted to observe the interactions between respiratory syncytial virus (RSV) and influenza A …

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Trial By Error: Guardian Columnist George Monbiot Discusses His Scathing Critique of the “Biopsychosocial” Approach to ME/CFS and Long Covid

By David Tuller, DrPH Earlier today I spoke with George Monbiot, a British investigative reporter and political activist, who has been a columnist for The Guardian for almost 30 years. He and I have been in occasional communication in recent years over an issue of mutual interest—the scandalous mistreatment of patients suffering from the devastating …

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Trial By Error: Senator Bernie Sanders’ $10 Billion Long Covid “Moonshot” Proposal

By David Tuller, DrPH On April 9th, Senator Bernie Sanders, the independent senator from Vermont who votes with the Democrats, unveiled an ambitious $10 billion “moonshot” proposal to fund research into Long Covid. The proposal has raised hopes among patients with the disease or cluster of diseases now being called ME/CFS—as well as concerns that …

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Trial By Error: An Interview with the Authors of the European ME Alliance Survey of 11,000+ Patients

By David Tuller, DrPH Earlier this month, the European Myalgic Encephalomyelitis Alliance (EMEA) released a 235-page report on a survey of ME/CFS patients in Europe titled “Same disease, different approaches and experiences.”  The authors are Arild Angelsen, a board member of the Norwegian ME Association and a professor at the School of Economics and Business …

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Trial By Error: REGAIN Team Responds to Criticism with Unconvincing Defenses of Methodological Missteps

By David Tuller, DrPH In recent weeks, I have been urging The BMJ to correct a flawed University of Warwick trial of an online mental and physical health rehab program for people with prolonged symptoms at least three months after hospitalization for Covid-19. The primary outcome was health-related quality of life, assessed with a measure …

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Trial By Error: A New Study from Exeter on “Brain Training” for Treatment of Post-Covid Cognitive Problems

By David Tuller, DrPH The University of Exeter is now recruiting for a study of “brain training” as a treatment for prolonged cognitive dysfunction after a bout of Covid-19. I found out about this via a post on X. The post highlighted a message that had been sent to an unidentified patient from their medical …

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Trial By Error: In England, Conflicts Between Families and Hospitals Threaten the Lives of Young Women with ME

By David Tuller, DrPH ME patients and advocates in England have been alarmed by a series of ongoing cases in which the families of severely ill young women have struggled to convince hospitals to fit them with feeding tubes before they starve to death. I covered a similar situation last year in a piece about …

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