Virology
Protection against 2009 influenza H1N1 by immunization with 1918-like and classical swine viruses
By Vincent Racaniello | | Basic virology, Information
Influenza A viruses typically cause severe respiratory disease mainly in the very young or the elderly. The 2009 swine-origin H1N1 virus is unusual because it preferentially infects individuals under 35 years of age. We’ve previously noted that being older is a good defense against 2009 H1N1 influenza virus, in part because older people have antibodies that …
Virology lecture #6: RNA-directed RNA synthesis
By Vincent Racaniello | | Basic virology, Information
Download: .wmv (324 MB) | .mp4 (76 MB) Visit the virology W3310 home page for a complete list of course resources.
TWiV 69: They’re all safecrackers
By Vincent Racaniello | | This Week in Virology
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 vaccines, and a virus-like particle vaccine for chikungunya virus. This episode is sponsored by Data Robotics Inc. …
Virology lecture #5: Attachment and entry
By Vincent Racaniello | | Basic virology, Information
Download: .wmv (386 MB) | .mp4 (131 MB) There are some errors in this lecture – I’ll correct them during the next session. Visit the virology W3310 home page for a complete list of course resources.
Now playing: Viral plaque formation
By Vincent Racaniello | | Basic virology, Information
One of the most important procedures in virology is measuring the virus titer €“ the concentration of viruses in a sample. A widely used approach for determining the quantity of infectious virus is the plaque assay. In this technique, the spread of progeny viruses released by individually infected cells is restricted to neighboring cells by …
Virology lecture #4: Structure of viruses
By Vincent Racaniello | | Basic virology
Download: .wmv (394 MB) | .mp4 (110 MB) Visit the virology W3310 home page for a complete list of course resources.
David Tuller
Trial By Error: More on the Canadian Long COVID Trial with Plans to Lie to Participants Receiving an Exercise Intervention
By David Tuller, DrPH I recently posted a blog about the protocol for a Canadian Long COVID exercise trial in which the investigators proposed lying to the participants about the nature of both the study and the intervention being assessed. While acknowledging that a significant number of people with Long COVID report experiencing post-exertional malaise …
Trial By Error: In Protocol for Long COVID Exercise Trial, Investigators Advocate Lying to Participants
By David Tuller, DrPH Researchers are planning yet another trial of a rehabilitative exercise program for Long COVID—but, in this one, they propose to lie to all the participants about the nature of the study and the intervention being investigated. BMJ Open has recently published a paper called “Pursuing Reduction in Fatigue After COVID-19 via …
Trial By Error: Some Things I’ve Read Recently: Anil van der Zee on Sex, “Mold Warrior” Johnson, and a Rant Against the Word “Journey”
By David Tuller, DrPH Anil van der Zee says “Fuck M.E.” One aspect of ME and ME/CFS that receives perhaps too little attention is the impact on someone’s sex life. Engaging in sexual activity takes a significant amount of energy—and is therefore likely to trigger post-exertional malaise for many with this illness. Especially for those …
Trial By Error: Some Things I’ve Read Recently–Aboriginals and Long COVID, Tips for Disability Claims, Profile of Ron Davis
By David Tuller, DrPH Failure to address Long COVID in Australian Aboriginal communities Croakey Health Media is a small but feisty Australian news outlet that covers social and structural inequities in healthcare. Croakey recently published “a call for action to address Long COVID in Aboriginal communities,” which focused in particular on the situation in the …
Trial By Error: Journalist Simon Spichak on Lack of Focus on Post-Exertional Malaise in Long COVID Exercise Trials
By David Tuller, DrPH According to the headline of a recent article in The Sick Times, “less than 20% of Long COVID trials involving exercise even mention post-exertional malaise.” The news organization analyzed the registration records for Long COVID clinical trials and found that only a small minority assess or take into account post-exertional malaise (PEM), …
Trial By Error: JAMA Touts Long COVID Exercise Trial with Clinically Insignificant Results; Most LC Exercise Trials Ignore PEM, Per Sick Times
By David Tuller, DrPH In its current “Medical News in Brief” section, JAMA is touting and amplifying the questionable claims of a flawed trial to treat or prevent Long COVID published by one of the journals under its umbrella—JAMANetworkOpen. The JAMA headline: “Resistance Training Improves Long COVID Outcomes.” Technically, the headline is true. In the …