Virology
Virology lecture #10: Transcription and RNA processing
By Vincent Racaniello | | Basic virology, Information
Download: .wmv (331 MB) | .mp4 (71 MB) Presented by guest lecturer Saul Silverstein, Ph.D. Visit the virology W3310 home page for a complete list of course resources.
XMRV not detected in Dutch chronic fatigue patients
By Vincent Racaniello | | Basic virology, Information
The suggestion that the retrovirus XMRV is the etiologic agent of chronic fatigue syndrome (CFS) arose from a study in which the virus was found in 68 of 101 US patients. The virus was not detected in two independent studies of 186 and 170 CFS patients in the United Kingdom. A new Dutch study has also …
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Virology lecture #9: Replication of DNA virus genomes
By Vincent Racaniello | | Basic virology, Information
Download: .wmv (352 MB) | .mp4 (74 MB) Presented by guest lecturer Saul Silverstein, Ph.D. Visit the virology W3310 home page for a complete list of course resources.
Virology lecture #8: Translation
By Vincent Racaniello | | Basic virology, Information
Download: .wmv (298 MB) | .mp4 (65 MB) My apologies for the poor audio in this lecture: I neglected to turn on my lapel mic and the entire session was recorded on the microphone in my laptop – which was across the room. Visit the virology W3310 home page for a complete list of course …
Architecture of a bullet-shaped virus
By Vincent Racaniello | | Basic virology, Information
Since electron micrographs first revealed the bullet-shaped morphology of vesicular stomatitis virus (a virus related to rabies virus), understanding the architecture has been elusive. It was known that the RNA genome is wrapped in a helical structure by the viral nucleocapsid (N) protein, but how this structure was encased by the viral matrix (M) protein …
TWiV #70: Hacking aphid behavior
By Vincent Racaniello | | This Week in Virology
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove On episode #70 of the podcast ‘This Week in Virology’, Vincent, Dickson, and Alan consider a broad spectrum antiviral against enveloped viruses, how a plant virus induces chemical signals in the host to maximize its spread, a new way to preserve viral vaccines at tropical temperatures, and …
David Tuller
Trial By Error: Claims Built on Fraudulent Trials Should Be Ignored
By David Tuller, DrPH When researchers cite fraudulent studies in support of their claims, it is best not to take anything they write at face value. That is certainly the case with a recent paper titled “Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach to promote recovery,” published …
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Trial By Error: Is Professor Crawley Retired from Bristol, or Isn’t She?
By David Tuller, DrPH Professor Esther Crawley, the methodologically and ethically challenged pediatrician and former grant queen at the University of Bristol, retired from medical practice and, apparently, from academia at some point in the recent past. So why does her name still appear on websites as if she were an active participant in research …
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Trial By Error: Norway Disability Case Exposes Flaws in Draft Guideline for “Long-Term Fatigue–including ME/CFS”
By David Tuller, DrPH A recent disability case in Norway provides a good example of why the draft of a new guideline for “long-term fatigue—including ME/CFS” is so problematic. As I reported last week, the draft guideline, produced by the Norwegian Directorate of Health*, generally favors the biopsychosocial approach. The guideline offers few specifics about …
Trial By Error: Why is Professor Crawley Still on the COFFI Steering Committee?
By David Tuller, DrPH Several years ago, the leaders of the biopsychosocial ideological brigades decided to create the Collaborative On Fatigue and related symptoms Following Infection, or COFFI. According to its website, COFFI’s “overarching aim” is “to investigate factors influencing the development of long-term symptoms (in particular fatigue) following certain infectious diseases.” Akershus University Hospital …
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Trial By Error: Aussie GPs Still Push Graded Exercise Therapy
By David Tuller, DrPH When I was in Australia for the first time in 2018, it was clear that the country’s general practitioners were fervent supporters of the biopsychosocial ideology when it came to ME/CFS. That hasn’t changed, according to a recent exchange of views published in the Australian Journal of General Practice. The debate …
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Trial By Error: Dutch Agency Funds CBT Training Program Based on Flawed Long COVID Trial
By David Tuller, DrPH Here is how bullshit replicates itself in today’s medical world: Conduct a flawed trial, declare success despite serious questions, then develop health policy based on these hyped-up claims. ZonMW, a major Dutch healthcare funding agency, is supporting a new program led by Professor Hans Knoop, a longtime supporter of the fraudulent …
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