Virology
TWiV 141: Mickey gets HCV
By Vincent Racaniello | | This Week in Virology
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Matt Evans Matt Evans joins Vincent, Rich, Dickson, and Alan to deconstruct a mouse model for hepatitis C virus infection. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV141.mp3″] Click the arrow above to play, or right-click to download TWiV #141 (117 MB .mp3, 97 minutes). Subscribe to TWiV (free) in iTunes , at …
Happy as a clam? Maybe not.
By Vincent Racaniello | | Uncategorized
This article was written for extra credit by a student in my recently concluded virology course. by Adriana Lopez The expression Happy as a Clam€ comes with new meaning as hepatitis A virus has been detected in clams, mussels, and oysters in markets for human consumption. As bivalve shellfish are excellent bio-accumulators of contaminants and chemicals, …
TWiV 140: An aptitude for microbicides
By Vincent Racaniello | | This Week in Virology
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Judy Lieberman Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV140.mp3″] Click the arrow above to play, or right-click to download TWiV #140 (110 MB .mp3, 92 minutes). Subscribe to TWiV (free) in iTunes , at the …
Poliomyelitis after a twelve year incubation period
By Vincent Racaniello | | Basic virology, Information
Analysis of poliovirus recovered from the stool of a patient with fatal poliomyelitis revealed that she had been infected with the virus 12 years earlier, probably when one of her children received the oral poliovirus vaccine. This case has the longest known incubation period for vaccine-derived poliomyelitis, and highlights our still rudimentary understanding of how …
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TWiM 10: A symbiotic cloaking device
By Vincent Racaniello | | This Week in Microbiology
Hosts: Vincent Racaniello, Michael Schmidt, Dickson Despommier, Margaret McFall-Ngai, and Elio Schaecter On episode #10 of the podcast This Week in Microbiology, Vincent, Margaret, Elio, Michael and Dickson discuss the symbiosis between the Hawaiian bobtail squid and the luminous, gram-negative bacterium Vibrio fischeri. [powerpress url=”http://traffic.libsyn.com/twimshow/TWiM010.mp3″] Click the arrow above to play, or right click to download TWiM #10 (47 MB, …
TWiV 139: Honey, I shrunk the virus
By Vincent Racaniello | | This Week in Virology
Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV139.mp3″] Click the arrow above to play, or right-click to download TWiV #139 (96 MB .mp3, 80 minutes). Subscribe to TWiV (free) in …
David Tuller
Trial By Error: More on the Canadian Long COVID Trial with Plans to Lie to Participants Receiving an Exercise Intervention
By David Tuller, DrPH I recently posted a blog about the protocol for a Canadian Long COVID exercise trial in which the investigators proposed lying to the participants about the nature of both the study and the intervention being assessed. While acknowledging that a significant number of people with Long COVID report experiencing post-exertional malaise …
Trial By Error: In Protocol for Long COVID Exercise Trial, Investigators Advocate Lying to Participants
By David Tuller, DrPH Researchers are planning yet another trial of a rehabilitative exercise program for Long COVID—but, in this one, they propose to lie to all the participants about the nature of the study and the intervention being investigated. BMJ Open has recently published a paper called “Pursuing Reduction in Fatigue After COVID-19 via …
Trial By Error: Some Things I’ve Read Recently: Anil van der Zee on Sex, “Mold Warrior” Johnson, and a Rant Against the Word “Journey”
By David Tuller, DrPH Anil van der Zee says “Fuck M.E.” One aspect of ME and ME/CFS that receives perhaps too little attention is the impact on someone’s sex life. Engaging in sexual activity takes a significant amount of energy—and is therefore likely to trigger post-exertional malaise for many with this illness. Especially for those …
Trial By Error: Some Things I’ve Read Recently–Aboriginals and Long COVID, Tips for Disability Claims, Profile of Ron Davis
By David Tuller, DrPH Failure to address Long COVID in Australian Aboriginal communities Croakey Health Media is a small but feisty Australian news outlet that covers social and structural inequities in healthcare. Croakey recently published “a call for action to address Long COVID in Aboriginal communities,” which focused in particular on the situation in the …
Trial By Error: Journalist Simon Spichak on Lack of Focus on Post-Exertional Malaise in Long COVID Exercise Trials
By David Tuller, DrPH According to the headline of a recent article in The Sick Times, “less than 20% of Long COVID trials involving exercise even mention post-exertional malaise.” The news organization analyzed the registration records for Long COVID clinical trials and found that only a small minority assess or take into account post-exertional malaise (PEM), …
Trial By Error: JAMA Touts Long COVID Exercise Trial with Clinically Insignificant Results; Most LC Exercise Trials Ignore PEM, Per Sick Times
By David Tuller, DrPH In its current “Medical News in Brief” section, JAMA is touting and amplifying the questionable claims of a flawed trial to treat or prevent Long COVID published by one of the journals under its umbrella—JAMANetworkOpen. The JAMA headline: “Resistance Training Improves Long COVID Outcomes.” Technically, the headline is true. In the …