TWiM 30: Unraveling melioidosis and insulin resistance

On episode #30 of the science show This Week in Microbiology, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor. You can find TWiM #30 at microbeworld.org/twim.

Building the perfect bug

This past February I was interviewed by the Australian Broadcasting Company on the topic of the Fouchier and Kawaoka experiments on avian influenza virus H5N1. The video, Building the Perfect Bug, has been released by Journeyman Pictures and includes interviews with S.T. Lai, Laurie Garrett, Michael Osterholm, and Ron Fouchier (transcript available). It is far too …

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TWiP 38: How to Trichomonas

On episode #38 of the science show This Week in Parasitism, Vincent and Dickson tackle the backlog of listener email, then consider the life cycle and pathogenesis of Trichomonas vaginalis, the flagellated protozoan transmitted by sexual contact. You can find TWiP #38 at microbeworld.org/twip.

TWiV 177: Live in Dublin

On episode #177 of the science show This Week in Virology, Vincent, Connor Bamford, Wendy Barclay, and Ron Fouchier discussed avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland. You can find TWiV #177 at www.microbe.tv/twiv.

NSABB reverses decision on publication of H5N1 results

The National Science Advisory Board for Biosecurity (NSABB) has re-examined two manuscripts on the transmissibility of influenza H5N1 virus in ferrets: After careful deliberation, the NSABB unanimously recommended that this revised Kawaoka manuscript should be communicated in full. The NSABB also recommended, in a 12 to 6 decision, the communication of the data, methods, and …

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Educating the world about microbes

I just returned from Dublin where I was honored to receive the Peter Wildy Prize for Microbiology Education from the Society for General Microbiology. This prize is awarded annually for an outstanding contribution to microbiology education, including university teaching, education of the general public, school pupils or professional groups. Below is a video of my acceptance …

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Trial By Error: Claims Built on Fraudulent Trials Should Be Ignored

By David Tuller, DrPH When researchers cite fraudulent studies in support of their claims, it is best not to take anything they write at face value. That is certainly the case with a recent paper titled “Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach to promote recovery,” published …

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Trial By Error: Is Professor Crawley Retired from Bristol, or Isn’t She?

By David Tuller, DrPH Professor Esther Crawley, the methodologically and ethically challenged pediatrician and former grant queen at the University of Bristol, retired from medical practice and, apparently, from academia at some point in the recent past. So why does her name still appear on websites as if she were an active participant in research …

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Trial By Error: Norway Disability Case Exposes Flaws in Draft Guideline for “Long-Term Fatigue–including ME/CFS”

By David Tuller, DrPH A recent disability case in Norway provides a good example of why the draft of a new guideline for “long-term fatigue—including ME/CFS” is so problematic.  As I reported last week, the draft guideline, produced by the Norwegian Directorate of Health*, generally favors the biopsychosocial approach. The guideline offers few specifics about …

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Trial By Error: Why is Professor Crawley Still on the COFFI Steering Committee?

By David Tuller, DrPH Several years ago, the leaders of the biopsychosocial ideological brigades decided to create the Collaborative On Fatigue and related symptoms Following Infection, or COFFI. According to its website, COFFI’s “overarching aim” is “to investigate factors influencing the development of long-term symptoms (in particular fatigue) following certain infectious diseases.” Akershus University Hospital …

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Trial By Error: Aussie GPs Still Push Graded Exercise Therapy

By David Tuller, DrPH When I was in Australia for the first time in 2018, it was clear that the country’s general practitioners were fervent supporters of the biopsychosocial ideology when it came to ME/CFS. That hasn’t changed, according to a recent exchange of views published in the Australian Journal of General Practice.  The debate …

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Trial By Error: Dutch Agency Funds CBT Training Program Based on Flawed Long COVID Trial

By David Tuller, DrPH Here is how bullshit replicates itself in today’s medical world: Conduct a flawed trial, declare success despite serious questions, then develop health policy based on these hyped-up claims. ZonMW, a major Dutch healthcare funding agency, is supporting a new program led by Professor Hans Knoop, a longtime supporter of the fraudulent …

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