Virology
TWiV 900: Burning down the mouse
By Vincent Racaniello | | This Week in Virology
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 900 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Fighting Viruses with Viruses
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey Errors during viral replication can give rise to shortened and/or rearranged genomic sequences known as “defective viral genomes” (DVGs). Because DVGs often lack critical elements needed for replication and formation of new viral particles, virions containing DVGs can only complete a replication cycle if they co-infect a cell together with respective …
TWiV 896: Memory B cells, the way we were
By Vincent Racaniello | | This Week in Virology
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Click arrow to playDownload TWiV 896 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at …
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
By Vincent Racaniello | | This Week in Virology
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.
TWiV 894: Dinner with the TMPRSS family
By Vincent Racaniello | | This Week in Virology
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.
TWiV 891: LLOV in the time of Ebola
By Vincent Racaniello | | This Week in Virology
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber's bats in Hungary.
David Tuller
Trial By Error: Claims Built on Fraudulent Trials Should Be Ignored
By David Tuller, DrPH When researchers cite fraudulent studies in support of their claims, it is best not to take anything they write at face value. That is certainly the case with a recent paper titled “Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach to promote recovery,” published …
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Trial By Error: Is Professor Crawley Retired from Bristol, or Isn’t She?
By David Tuller, DrPH Professor Esther Crawley, the methodologically and ethically challenged pediatrician and former grant queen at the University of Bristol, retired from medical practice and, apparently, from academia at some point in the recent past. So why does her name still appear on websites as if she were an active participant in research …
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Trial By Error: Norway Disability Case Exposes Flaws in Draft Guideline for “Long-Term Fatigue–including ME/CFS”
By David Tuller, DrPH A recent disability case in Norway provides a good example of why the draft of a new guideline for “long-term fatigue—including ME/CFS” is so problematic. As I reported last week, the draft guideline, produced by the Norwegian Directorate of Health*, generally favors the biopsychosocial approach. The guideline offers few specifics about …
Trial By Error: Why is Professor Crawley Still on the COFFI Steering Committee?
By David Tuller, DrPH Several years ago, the leaders of the biopsychosocial ideological brigades decided to create the Collaborative On Fatigue and related symptoms Following Infection, or COFFI. According to its website, COFFI’s “overarching aim” is “to investigate factors influencing the development of long-term symptoms (in particular fatigue) following certain infectious diseases.” Akershus University Hospital …
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Trial By Error: Aussie GPs Still Push Graded Exercise Therapy
By David Tuller, DrPH When I was in Australia for the first time in 2018, it was clear that the country’s general practitioners were fervent supporters of the biopsychosocial ideology when it came to ME/CFS. That hasn’t changed, according to a recent exchange of views published in the Australian Journal of General Practice. The debate …
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Trial By Error: Dutch Agency Funds CBT Training Program Based on Flawed Long COVID Trial
By David Tuller, DrPH Here is how bullshit replicates itself in today’s medical world: Conduct a flawed trial, declare success despite serious questions, then develop health policy based on these hyped-up claims. ZonMW, a major Dutch healthcare funding agency, is supporting a new program led by Professor Hans Knoop, a longtime supporter of the fraudulent …
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