TWiV 354: The cat in the HAART

On episode #354 of the science show This Week in Virology, the esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus. You can find TWiV #354 at www.microbe.tv/twiv.

Why do we still use Sabin poliovirus vaccine?

The Sabin infectious, attenuated poliovirus vaccines are known to cause vaccine-associated paralysis in a small number of recipients. In contrast, the Salk inactivated vaccine does not cause poliomyelitis. Why are the Sabin vaccines still used globally? The answer to this question requires a brief visit to the history of poliovirus vaccines. The inactivated poliovirus vaccine (IPV) developed by …

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ASM Live at ICAAC/ICC 2015

ASM Live will be broadcast from ICAAC/ICC 2015 in San Diego, CA, where host Michael Schmidt, PhD, Professor and Vice Chairman of Microbiology and Immunology at the Medical University of South Carolina, and co-host of This Week in Microbiology, will interview researchers about their work. Streaming will take place at the San Diego Convention Center, Room 29B, and meeting registrants …

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TWiV 353: STING and the antiviral police

On episode #353 of the science show This Week in Virology, the TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles. You can find TWiV #353 at www.microbe.tv/twiv.

Shedding poliovirus for 28 years

An immunodeficient individual has been excreting poliovirus in his stool for 28 years. Such chronic excreters pose a threat to the poliovirus eradication program. Since its inception in 1988 by the World Health Organization, the poliovirus eradication program has relied on the use of the infectious, attenuated vaccine strains produced by Albert Sabin. These viruses …

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Shelves and mentors

When I became Peter Palese’s first Ph.D. student in 1976, his laboratory at Mt. Sinai School of Medicine in New York City was in dire need of shelves. The laboratory benches (pictured) had no room for storing the many bottles of reagents that I was beginning to generate. When I told Peter that his laboratory needed shelves, …

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Trial By Error: My Letter to Lead REGAIN Trial Investigator Seeking Correction of Bogus Claims of Clinical Effectiveness

By David Tuller, DrPH Two weeks ago, I sent a letter to The BMJ on behalf of myself and 12 colleagues seeking a correction in a study published last month. The study, called Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial,” claimed that the intervention …

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Trial By Error: We Asked BMJ to Correct a Paper; BMJ Requested a Rapid Response; We Have Declined

Leave a Comment / By David Tuller / 24 March 2024 By David Tuller, DrPH Two weeks ago, I sent a letter to The BMJ on behalf of myself and 12 colleagues seeking a correction in a study published last month. The study, called Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): …

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Trial By Error: David Putrino on 1) Australian Call to Scrap the Term “Long Covid” and 2) New Pre-Print on Sex Differences in LC

By David Tuller, DrPH Last week, just in time for Long Covid Awareness Day on Friday, the chief health officer of the Australian state of Queensland, John Gerrard, declared that the term “Long Covid” should be dropped. He based his argument on Queensland survey data suggesting that rates of prolonged disability after Covid-19 are similar …

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Trial By Error: Professor Chris Ponting on the NIH’s Findings and the Latest on the Genome-Wide Association Study Update

By David Tuller, DrPH When the US National Institutes of Health released its lengthy ME/CFS study last month with much fanfare and publicity, the London-based Science Media Centre asked Professor Chris Ponting, among other experts, to provide comment. The study–“Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome”–was published by Nature Communications. It included in-depth findings …

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Trial By Error: Guardian Columnist George Monbiot Calls Out the GET/CBT Charlatans and the Fraudulent PACE Trial

By David Tuller, DrPH In a blistering take-down published on Tuesday, Guardian columnist George Monbiot indicted Professor Sir Simon Wessely, Professor Michael Sharpe and the rest of the GET/CBT ideological brigades for their decades-long promotion of discredited theories about and bogus research into the cluster of illnesses now being called ME/CFS. Those theories and research …

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Trial By Error: Letter to BMJ Seeking Correction in Study of Long Covid Physical-and-Mental Rehabilitation Program

By David Tuller, DrPH Last month, The BMJ published a study of a rehab intervention for Long Covid in which the authors made claims that were not borne out by the data. The study was called “Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN …

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