This Week in Evolution

TWiEVO 79: When the immune system is away, SARS-CoV-2 will play

2 July 2022 by Vincent Racaniello

Nels and Vincent discuss an analysis of the drivers of evolution of SARS-CoV-2 during chronic infections, indicating that a tradeoff exists between antibody evasion and fitness.

Hosts: Nels Elde and Vincent Racaniello

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Show notes at microbe.tv/twievo

TWiEVO 57: SARS-CoV-2 receptor binding evolution blooms

25 June 2020 by Vincent Racaniello

Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain.

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Show notes at microbe.tv/twievo

TWiEVO 56: Revising the drafts of coronavirus evolution

21 May 2020 by Vincent Racaniello

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, including understanding recurrent mutations in the viral genome, and the potential for re-emergence of the virus from an animal reservoir.

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DownloadÂ TWiEVO 56 (53 MB .mp3, 88 min)
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Show notes at microbe.tv/twievo

TWiEVO 55: Coronavirus evolution from soup to nuts

7 May 2020 by Vincent Racaniello

Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission.

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DownloadÂ TWiEVO 55 (45 MB .mp3, 74 min)
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Show notes at microbe.tv/twievo

TWiEVO 49: A giant podcast on giant viruses

29 November 2019 by Vincent Racaniello

Rich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany.

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Show notes at microbe.tv/twievo

TWiEVO 31: Virus archaeology, or when the human genome is the junk

19 May 2018 by Vincent Racaniello

Nels and Vincent present ancient hepatitis B virus genome sequences from Bronze Age to Medieval period human remains.

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DownloadÂ TWiEVO 31Â (49 MB .mp3, 81 min)
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Show notes at microbe.tv/twievo