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About viruses and viral disease

Immune

Red blood cells are immune sentinels

12 November 2021 by Vincent Racaniello

Did you know that the innate immune DNA sensor TLR9 is on the membrane of red blood cells? I didn’t know that. To learn about why it’s there, listen to Immune episode #50. In that episode we review evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.

Filed Under: Immune, Information Tagged With: anemia, DNA, immune, immunology, inflammation, innate immune sensor, red blood cell, sepsis, TLR9

Immune 3: Two epitopes, four serotypes, and a partridge in a pear tree

16 December 2017 by Vincent Racaniello

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus.

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Filed Under: Immune Tagged With: ADE, antibody dependent enhancement, antibody therapy, bispecific antibody, dengue virus, Dengvaxia, immune, immunology, monoclonal antibody, passive vaccine, zika virus

Immune 2: Lymphocytes after dark

25 November 2017 by Vincent Racaniello

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph is circadian – it is dependent on the time of day.

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Show notes at microbe.tv/immune

Filed Under: Immune Tagged With: 24 hour clock, adaptive immunity, B cell, circadian, clock gene, immune, immunology, lymph, lymph node, lymphocyte, T cell

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by Vincent Racaniello

Earth’s virology Professor
Questions? virology@virology.ws

With David Tuller and
Gertrud U. Rey

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