virology blog
About viruses and viral disease
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Download TWiV 902 (76 MB .mp3, 127 min)
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Show notes at microbe.tv/twiv
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.
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Download TWiV 901 (36 MB .mp3, 60 min)
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Show notes at microbe.tv/twiv
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Download TWiV 900 (65 MB .mp3, 108 min)
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Show notes at microbe.tv/twiv
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.
Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld
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Download TWiV 896 (65 MB .mp3, 108 min)
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Show notes at microbe.tv/twiv
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.
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Download TWiV 895 (33 MB .mp3, 54 min)
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Show notes at microbe.tv/twiv
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Download TWiV 894 (60 MB .mp3, 100 min)
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Show notes at microbe.tv/twiv
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi
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Download TWiV 891 (65 MB .mp3, 108 min)
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Show notes at microbe.tv/twiv
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Download TWiV 890 (65 MB .mp3, 108 min)
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Show notes at microbe.tv/twiv
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa.
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Download TWiV 889 (52 MB .mp3, 53 min)
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Show notes at microbe.tv/twiv
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Richard Plemper
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Download TWiV 888 (65 MB .mp3, 108 min)
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Show notes at microbe.tv/twiv