TWiV 477: Raiders of the lost Arc

The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA within vesicles across the synapse.

Click arrow to play
Download TWiV 477 (63 MB .mp3, 103 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

Metabolic manipulations in virus-infected cells

glycolysisThe large quantities of viral macromolecules and virus particles that are produced in an infected cell impose heavy demands on the host. Synthesis of the building blocks of a virus particle – nucleotides, amino acids, and sometimes fatty acids – requires energy, typically in the form of ATP. Synthesis of viral proteins and genomes, and transport of viral components in the cell also require energy. Because of these needs, viral infections often lead to alterations in the energy-generating and precursor synthesizing pathways of a cell. Two recent examples illustrate how virus infection can alter host metabolism.

[click to continue…]

TWiV 476: In ACOD1 we trust

Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA.

Click arrow to play
Download TWiV 476 (63 MB .mp3, 105 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

A virus and a paradox in a 439 year old mummy

HBV mummy

Vesicopustular rash on face (C) and arm (D) of 439 year old mummy. Image credit.

A study done in 1985 on a 16th century Italian mummy suggested that the two year old child had smallpox. Recent sequence analysis of tissues from the mummy now reveal the presence of hepatitis B virus, not smallpox virus. The sequence of the viral genome suggests that HBV entered the human population well before 1500.

[click to continue…]

TWiV 475: Everything is viral

In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017.

Click arrow to play
Download TWiV 475 (67 MB .mp3, 110 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

TWiV 474: Call me fish meal

The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth’s waters.

Click arrow to play
Download TWiV 474 (62 MB .mp3, 103 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

Bodo saltans virus, an abundant giant aquatic Mimivirus

Bodo saltans

Bodo saltans

The discovery of Mimivirus in a French cooling tower amazed virologists and changed our view of the biology and evolution of giant viruses. Since then, many other giant viruses have been identified, and with three exceptions, they all appear to infect species of Acanthamoeba. Now a new member of the Mimivirus family has been discovered that infects the flagellated eukaryote Bodo saltans (pictured: image credit).

[click to continue…]

TWiV 473: Assessing a risk and infecting you twice

The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.

Click arrow to play
Download TWiV 473 (67 MB .mp3, 110 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

Antibodies mediate severe dengue in humans

Antibody dependent enhancementSevere dengue virus disease, also known as dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), is most likely to occur in previously infected individuals experiencing a second encounter with a different serotype. A specific range of serum antibody titers has been shown to enhance viral replication in cell culture and in animal models, and now in humans.

[click to continue…]

TWiV 472: The riddle of the skinks

The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard.

Click arrow to play
Download TWiV 472 (69 MB .mp3, 114 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv