TWiV 485: Fishing with defective flies

The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses.

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Mosquito blood feeding is not a free lunch

Wyeomyia smithiiImagine that we could change all the mosquitoes in the world so that they would no longer take a blood meal, and then consider the impact on transmission of viruses and parasites. Before you say impossible, you should know that Nature has already done it – not all mosquitoes take blood meals.

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Virus Watch: Buckyball Viruses

In this short video, I show you how to make different types of virus particles using the small magnetic spheres called Buckyballs.

TWiV 484: Float like a mimivirus STING like a bat

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.

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TWiV 483: Every infection is unhappy in its own way

Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells.

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Influenza virus in the eye

By Gertrud U. Rey

Gertrud Rey is a trained virologist residing in Atlanta, Georgia. During the day, she works as a consultant in a biotech patent law firm, but spends much of her free time as a science communicator. She was a guest on TWiV 179 and 424.

Although the dominant mode of transmission for influenza virus is via the respiratory route, there is growing evidence to suggest that various human and avian influenza viruses are capable of entering the body following ocular exposure.

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TWiV 482: Don’t EVEome without antibody expressed

The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome.

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Ebolavirus infections but no outbreak

EbolavirusEbolavirus infections are feared because of the high fatality rate observed during outbreaks, from 25-90%. But there is evidence that far less serious Ebolavirus infections may occur in the absence of outbreaks.

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TWiV 481: And biles to go before I delete

The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza.

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Defective viral genomes and severe influenza

Defective influenza virus RNAsThe virulence of a virus – its capacity to cause disease – is determined by both viral and host factors. Even among healthy individuals, infection with a particular virus may have different outcomes ranging from benign to lethal. The study of influenza viruses that cause mild or fatal outcomes reveals that defective viral genomes play a role in determining viral virulence.

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