The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Click arrow to play Download TWiV 537 (63 MB .mp3, 104 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
When I first entered the field of virology, in the 1970s, the definition of virus included the then-correct observation that no viral genome encoded any part of the translational apparatus. This dictum was shattered by the discovery of giant viruses which were found to encode tRNAs, aminoacyl tRNA syntheses, and many proteins involved in translation. …
The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to play Download TWiV 484 (53 MB .mp3, 87 min) Subscribe (free): iTunes, RSS, email …
TWiV 484: Float like a mimivirus STING like a bat Read More »
If you know anything about me, you know that I’m mad about viruses. Although this madness extends to everything viral, I have a peculiar fondness for giant viruses. A new giant virus has been found that not only looks different from all the others, but has an amazing set of genes.
I just love it when long standing mysteries in virology are suddenly solved, typically by the use of new technologies. In this story, the long standing mystery was why poxvirus mRNAs have a stretch of poly(A) in their 5′-noncoding regions. The answer is that it allows the ribosome to preferentially translate these viral mRNAs over …
On episode #349 of the science show This Week in Virology, Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea. You can find TWiV #349 at www.microbe.tv/twiv.
