An important question about the retrovirus XMRV, which has been implicated in prostate cancer and chronic fatigue syndrome, is where the virus replicates in humans. Such information would provide clues about how infection might be transmitted. To date the virus has been detected in malignant prostate cells and in the peripheral blood mononuclear cells and …
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution located in the eponymous town on Long Island, New York. Over 400 scientists work there on a wide range of biological problems, including cancer, neurobiology, plant genetics, and genomics. CSHL has a storied research history, having hosted nine Nobel Laureates. But it is also well …
All mammalian genomes contain genes encoding Apobec proteins. Several members of this protein family (the name stands for apolipoprotein B mRNA editing complex) are induced by interferon and are intrinsic antiretroviral proteins. Apobec proteins inhibit the replication of XMRV, a new human retrovirus associated with prostate cancer and chronic fatigue syndrome. During retroviral replication, Apobec …
Inhibition of XMRV by a weapon of mass deamination Read More »
A new retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), first identified in tumor tissue of individuals with prostate cancer, was subsequently found in 68 of 101 US patients with chronic fatigue syndrome (CFS). XMRV was not detected in blood samples of 186 confirmed CFS patients in the United Kingdom. A second independent study in the …
XMRV not found in 170 additional UK chronic fatigue syndrome patients Read More »
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich are enthralled by movies of vaccinia virus plaque formation, then consider how repulsion of superinfection virions leads to rapid virus spread, and a therapeutic prostate cancer vaccine. This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 …
Fragments of an abundant protein produced by the prostate form amyloid fibrils that enhance infection of cells by human immunodeficiency virus type 1. These fibrils, called semen-derived enhancer of virus infection (SEVI), have been found to boost infection of prostate cells by the retrovirus XMRV. Is this evidence that XMRV causes prostate cancer? Because most …
XMRV infection is enhanced by prostatic protein fragments Read More »
