PB1-F2

Influenza A/Mexico/2009 (H1N1): Absence of crucial virulence marker

The second RNA segment of the influenza virus genome encodes two proteins, PB1 and PB1-F2.  The latter protein is believed to be an important determinant of virulence of influenza virus. Can we learn anything about the virulence of the new influenza virus H1N1 strains from a study of this protein? During influenza virus infection, PB1-F2 …

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Influenza virus RNA: Translation into protein

Let’s resume our discussion of the influenza virus genome. Last time we established that there are eight negative-stranded RNAs within the influenza virion, each coding for one or two proteins. Now we’ll consider how proteins are made from these RNAs. Figure 1 shows influenza RNA segment 2, which encodes two proteins: PB1 and PB1-F2. The …

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