Several mutations that arose during the 2013-2016 outbreak of Ebola virus in West Africa were previously found to increase infectivity for human cells. However, a study in two animal models show no effect of these mutations on disease. Among the many mutations identified among the hundreds of genome sequences obtained during the 2013-2016 Ebola virus epidemic, a …
Ebola virus mutations do not affect pathogenicity Read More »
What would happen to an RNA virus if its genome were placed in a bad neighborhood? The answer is that fitness plummets. RNA virus populations are not composed of a single defined nucleic acid sequence, but are dynamic distributions of many nonidentical but related members. In the past I have referred to these populations as quasispecies but …
The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak. You can find TWiV #431 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 431 (71 MB .mp3, 118 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Jeremy Luban, Aaron Lin, and Ted Diehl join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells. You can find TWiV #415 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV415.mp3″] Click arrow to play Download TWiV 415 (67 MB …
TWiV 415: Ebola pipettors and the philosopher’s clone Read More »
On episode #360 of the science show This Week in Virology, Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site. You can find TWiV #360 at …
On episode #340 of the science show This Week in Virology, the TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation. You can find TWiV #340 at www.microbe.tv/twiv.
